2-amino-3-(2,4-difluorophenyl)propanoic Acid

Base Information

• Chemical Name: 2-amino-3-(2,4-difluorophenyl)propanoic Acid
• CAS No.: 32133-35-0
• Molecular Formula: C9H9F2NO2
• Molecular Weight: 201.17
• Hs Code.: 2922499990
• European Community (EC) Number: 670-834-3
• DSSTox Substance ID: DTXSID70371794
• Mol file: 32133-35-0.mol

Synonyms:32133-35-0;2-amino-3-(2,4-difluorophenyl)propanoic Acid;2,4-Difluoro-DL-phenylalanine;dl-2,4-Difluorophenylalanine;MFCD00061302;D-2,4-DIFLUOROPHE;L-2,4-DIFLUOROPHE;SCHEMBL44972;L-Phenylalanine,2,4-difluoro-;DTXSID70371794;BCP10482;AKOS000195276;AKOS032963162;AB02418;AB16790;AB33470;CS-W006430;HY-W006430;PS-6485;AC-14972;SY044824;FT-0610100;FT-0654380;FT-0656290;2-amino-3-(2,4-difluorophenyl)propanoicAcid;EN300-1827097;A818534;A821163;2-azanyl-3-[2,4-bis(fluoranyl)phenyl]propanoic acid

Chemical Property of 2-amino-3-(2,4-difluorophenyl)propanoic Acid

Chemical Property:

• Vapor Pressure: 0.000344mmHg at 25°C
• Melting Point: 224 °C
• Refractive Index: 1.536
• Boiling Point: 306.1 °C at 760 mmHg
• Flash Point: 138.9 °C
• PSA: 63.32000
• Density: 1.379 g/cm³
• LogP: 1.61950
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: -1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 201.06013485
• Heavy Atom Count: 14
• Complexity: 213

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,4-Difluoro-DL-phenylalanine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1F)F)CC(C(=O)O)N

Technology Process of 2-amino-3-(2,4-difluorophenyl)propanoic Acid

There total 1 articles about 2-amino-3-(2,4-difluorophenyl)propanoic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ rac-2,4-difluorophenylalanine (32133-35-0,266360-60-5)

Guidance literature:

Entspr. Aldehyd, Hippursaeure (?);

Reference yield: 87.0%

rac-2,4-difluorophenylalanine (32133-35-0,266360-60-5) + C20H24N2O2*ClH + nickel dichloride (83864-14-6) → C29H29F2N3NiO3

Guidance literature:

With sodium carbonate; In methanol; at 65 ℃; diastereoselective reaction;

DOI:10.1002/ejoc.201700339

Reference yield:

rac-2,4-difluorophenylalanine (32133-35-0,266360-60-5) → 2-allyloxycarbonylamino-3-(2,4-difluorophenyl)-propanoic acid (748163-63-5)

Guidance literature:

Downstream raw materials:

2-allyloxycarbonylamino-3-(2,4-difluorophenyl)-propanoic acid