2,6-Difluoro-DL-phenylalanine

Base Information

• Chemical Name: 2,6-Difluoro-DL-phenylalanine
• CAS No.: 32133-39-4
• Molecular Formula: C9H9F2NO2
• Molecular Weight: 201.17
• Hs Code.: 2922499990
• European Community (EC) Number: 671-874-4
• DSSTox Substance ID: DTXSID90371796
• Mol file: 32133-39-4.mol

Synonyms:2,6-difluoro-dl-phenylalanine;32133-39-4;2-amino-3-(2,6-difluorophenyl)propanoic Acid;dl-2,6-Difluorophenylalanine;MFCD00061304;d,l-2,6-difluorophenyl-alanine;Phenylalanine,2,6-difluoro-;SCHEMBL188587;DTXSID90371796;AKOS000179016;AKOS016843244;AB02426;AB33494;AB93141;HY-W037785;PS-6617;SY044826;CS-0094297;FT-0610656;FT-0630317;FT-0657316;FT-0771566;EN300-1857655

Chemical Property of 2,6-Difluoro-DL-phenylalanine

Chemical Property:

• Vapor Pressure: 0.000478mmHg at 25°C
• Melting Point: 256-257oC
• Refractive Index: 1.536
• Boiling Point: 301.1 °C at 760 mmHg
• PKA: 2.20±0.10(Predicted)
• Flash Point: 135.9 °C
• PSA: 63.32000
• Density: 1.379 g/cm³
• LogP: 1.61950
• Storage Temp.: 2-8°C
• XLogP3: -1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 201.06013485
• Heavy Atom Count: 14
• Complexity: 203

Purity/Quality:

98%min ^*data from raw suppliers

2,6-Difluoro-DL-phenylalanine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C(=C1)F)CC(C(=O)O)N)F

Technology Process of 2,6-Difluoro-DL-phenylalanine

There total 1 articles about 2,6-Difluoro-DL-phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-amino-3-(2,6,-difluorophenyl)propanoic acid (32133-39-4,266360-62-7)

Guidance literature:

CHO, Hippursaeure (?);

Reference yield:

2'-chloro-4-biphenylcarbonyl chloride (80644-07-1) + 2-amino-3-(2,6,-difluorophenyl)propanoic acid (32133-39-4,266360-62-7) → 2-(2'-chlorobiphen-4-ylcarbonylamino)-3-(2,6-difluorophenyl)propionic acid

Guidance literature:

2'-chloro-4-biphenylcarbonyl chloride; 2-amino-3-(2,6,-difluorophenyl)propanoic acid; With sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; at 0 ℃; for 1.08333h;

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; water; pH=4;