1-(2-Diisopropylaminoethyl)piperazine

Base Information

• Chemical Name: 1-(2-Diisopropylaminoethyl)piperazine
• CAS No.: 59955-93-0
• Molecular Formula: C₁₂H₂₇N₃
• Molecular Weight: 213.366
• Hs Code.: 2933599590
• European Community (EC) Number: 673-641-2
• DSSTox Substance ID: DTXSID00371181
• Wikidata: Q82158440
• Mol file: 59955-93-0.mol

Synonyms:59955-93-0;1-(2-Diisopropylaminoethyl)piperazine;diisopropyl-(2-piperazin-1-yl-ethyl)-amine;1-(2-Diisopropylamino-ethyl)-piperazine;N-(2-piperazin-1-ylethyl)-N-propan-2-ylpropan-2-amine;N,N-Diisopropyl-N-(2-piperazin-1-ylethyl)amine;N,N-Bis(prop-2-yl)-2-(piperazin-1-yl)ethylamine;MFCD01320902;[2-(piperazin-1-yl)ethyl]bis(propan-2-yl)amine;N-isopropyl-N-(2-(piperazin-1-yl)ethyl)propan-2-amine;SCHEMBL945818;DTXSID00371181;N-[2-(Piperazin-1-yl)ethyl]-N-(prop-2-yl)propan-2-amine;AKOS000303282;TS-00440;CS-0317488;FT-0640648;1-(2-diisopropylaminoethyl)piperazine, AldrichCPR;A832551;BRD-K07769565-001-01-3;N-[2-(Piperazin-1-yl)ethyl]-N-(propan-2-yl)propan-2-amine

Chemical Property of 1-(2-Diisopropylaminoethyl)piperazine

Chemical Property:

• Vapor Pressure: 0.0134mmHg at 25°C
• Refractive Index: 1.467
• Boiling Point: 258.9 °C at 760 mmHg
• PKA: 10.65±0.28(Predicted)
• Flash Point: 91.2 °C
• PSA: 18.51000
• Density: 0.895 g/cm³
• LogP: 1.27710
• Storage Temp.: 2-8°C
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 213.220497874
• Heavy Atom Count: 15
• Complexity: 154

Purity/Quality:

99% ^*data from raw suppliers

1-(2-Diisopropylaminoethyl)piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)N(CCN1CCNCC1)C(C)C

Technology Process of 1-(2-Diisopropylaminoethyl)piperazine

There total 8 articles about 1-(2-Diisopropylaminoethyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.5%

piperazine (110-85-0) + piperazine dihydrochloride (142-64-3,8006-71-1) + 1-chloro-2-diisopropylaminoethane hydrochloride (4261-68-1) → N-isopropyl-N-(2-(piperazin-1-yl)ethyl)propan-2-amine (59955-93-0)

Guidance literature:

piperazine; piperazine dihydrochloride; In water; at 65 ℃; for 0.5h;

1-chloro-2-diisopropylaminoethane hydrochloride; In water; at 70 ℃; for 1h;

With sodium hydroxide; In water; at 20 ℃; Product distribution / selectivity;

Reference yield: 93.0%

1-[2-(diisopropyl)aminoethyl]piperazine dihydrochloride monohydrate → N-isopropyl-N-(2-(piperazin-1-yl)ethyl)propan-2-amine (59955-93-0)

Guidance literature:

With sodium hydroxide; In methanol; at 40 ℃; for 2h; Product distribution / selectivity;

Reference yield: 90.9%

piperazine (110-85-0) + 1-chloro-2-diisopropylaminoethane hydrochloride (4261-68-1) → N-isopropyl-N-(2-(piperazin-1-yl)ethyl)propan-2-amine (59955-93-0)

Guidance literature:

piperazine; With hydrogenchloride; In water; for 0.5h;

1-chloro-2-diisopropylaminoethane hydrochloride; In water; at 70 ℃; for 1h;

With sodium hydroxide; In water; at 20 ℃; Product distribution / selectivity;

upstream raw materials:

piperazine

piperazine dihydrochloride

1-chloro-2-diisopropylaminoethane hydrochloride

tert-butyl 4-(2-chloroethyl)tetrahydro-1(2H)-pyrazinecarboxylate

Refernces

• 1、 -. "PROCESS FOR PRODUCING PIPERAZINE DERIVATIVE". Page/Page column 20-22. . Retrieved 2010/11/25.