N--4-oxoisoxazolidine

Base Information

• Chemical Name: N--4-oxoisoxazolidine
• CAS No.: 80042-03-1
• Molecular Formula: C₁₂H₁₁NO₅
• Molecular Weight: 249.223
• Mol file: 80042-03-1.mol

Synonyms:N--4-oxoisoxazolidine

Chemical Property of N--4-oxoisoxazolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N--4-oxoisoxazolidine

There total 4 articles about N--4-oxoisoxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

N--4-hydroxyisoxazolidine (80041-99-2) → N--4-oxoisoxazolidine (80042-03-1)

Guidance literature:

With pyridine; chromium(VI) oxide; In dichloromethane; for 0.25h; Ambient temperature;

DOI:10.1055/s-1982-29825

Reference yield:

N-<(3-bromo-2-hydroxypropyl)oxy>phthalimide (80042-02-0) → N--4-oxoisoxazolidine (80042-03-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / t-Butylamine / 1 h / Ambient temperature

2: 50 percent / CrO₃, pyridine / CH₂Cl₂ / 0.25 h / Ambient temperature

With pyridine; chromium(VI) oxide; tert-butylamine; In dichloromethane;

DOI:10.1055/s-1982-29825

Reference yield:

N-hydroxyphthalimide (524-38-9) → N--4-oxoisoxazolidine (80042-03-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 35 percent / Et₃N / dimethylformamide / 12 h

2: HBr / CHCl₃ / 1 h

3: 100 percent / tert-BuNH₂ / 1 h / Ambient temperature

4: 45 percent / pyridinium dichromate / CH₂Cl₂ / 15 h / Heating

With dipyridinium dichromate; hydrogen bromide; tert-butylamine; triethylamine; In dichloromethane; chloroform; N,N-dimethyl-formamide;

DOI:10.1021/jo00342a029

upstream raw materials:

N--4-hydroxyisoxazolidine

N-<(3-bromo-2-hydroxypropyl)oxy>phthalimide

N-hydroxyphthalimide

N-<(2,3-epoxypropyl)oxy>phthalimide

Refernces

• 1、 Amlaiky, Nourdine,Leclerc, Gerard,Carpy, Alain. "Unusual Reaction of N-Hydroxyphthalimido Ethers Leading to Oxygen-Nitrogen Heterocycles". . p. 517 - 523. Retrieved 2007/10/02.