2-METHOXY-5-NITROPHENYL ISOTHIOCYANATE

Base Information

• Chemical Name: 2-METHOXY-5-NITROPHENYL ISOTHIOCYANATE
• CAS No.: 71793-51-6
• Molecular Formula: C8H6N2O3S
• Molecular Weight: 210.213
• Mol file: 71793-51-6.mol

Synonyms:2-Methoxy-5-nitrophenylisothiocyanate;

Chemical Property of 2-METHOXY-5-NITROPHENYL ISOTHIOCYANATE

Chemical Property:

• Vapor Pressure: 7.03E-06mmHg at 25°C
• Melting Point: 105 °C
• Refractive Index: 1.604
• Boiling Point: 388.1 °C at 760 mmHg
• Flash Point: 188.5 °C
• PSA: 99.50000
• Density: 1.33 g/cm³
• LogP: 2.86090

Purity/Quality:

98%min ^*data from raw suppliers

2-isothiocyanato-1-methoxy-4-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHOXY-5-NITROPHENYL ISOTHIOCYANATE

There total 3 articles about 2-METHOXY-5-NITROPHENYL ISOTHIOCYANATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

carbon disulfide (75-15-0,12122-00-8) + 3-amino-4-methoxynitrobenzene (99-59-2) → 2-methoxy-5-nitrophenyl isothiocyanate (71793-51-6)

Guidance literature:

With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 5 - 10 ℃; for 4h;

DOI:10.1007/s11030-021-10333-0

Reference yield:

thiophosgene (463-71-8) + 3-amino-4-methoxynitrobenzene (99-59-2) → 2-methoxy-5-nitrophenyl isothiocyanate (71793-51-6)

Guidance literature:

DOI:10.1039/jr9340000174

Reference yield:

→ 2-methoxy-5-nitrophenyl isothiocyanate (71793-51-6)

Guidance literature:

2-Methoxy-5-nitro-anilin, Thiophosgen, wss. Salzsaeure;

upstream raw materials:

thiophosgene

3-amino-4-methoxynitrobenzene

carbon disulfide

Downstream raw materials:

2-(2,4-Dinitro-phenyl)-N-(2-methoxy-5-nitro-phenyl)-3-oxo-thiobutyramide

2-Cyano-N-(2-methoxy-5-nitro-phenyl)-2-[1-phenyl-meth-(E)-ylidene-hydrazinocarbonyl]-thioacetamide

C₁₆H₁₇N₇O₃S₂

N-(indan-5-yl)-2-[3-(2-methoxy-5-nitrophenyl)thioureido-2-(3-thienyl)]acetamide

Refernces