1-(2-METHOXYPHENYL)-4-(2-CHLOROETHYL)PIPERAZINE DIHYDROCHLORIDE

Base Information

• Chemical Name: 1-(2-METHOXYPHENYL)-4-(2-CHLOROETHYL)PIPERAZINE DIHYDROCHLORIDE
• CAS No.: 43091-72-1
• Molecular Formula: C13H21Cl3N2O
• Molecular Weight: 254.76
• Hs Code.: 2933599090
• Mol file: 43091-72-1.mol

Synonyms:1-(2-Chloroethyl)-4-(2-methoxyphenyl)piperazine;

Chemical Property of 1-(2-METHOXYPHENYL)-4-(2-CHLOROETHYL)PIPERAZINE DIHYDROCHLORIDE

Chemical Property:

• Melting Point: 240 °C
• Boiling Point: 374 °C at 760 mmHg
• PKA: 6.65±0.40(Predicted)
• Flash Point: 180 °C
• PSA: 15.71000
• Density: 1.128±0.06 g/cm3(Predicted)
• LogP: 3.66290

Purity/Quality:

99% ^*data from raw suppliers

4-(2-CHLOROETHYL)-1-(2-METHOXYPHENYL)PIPERAZINE DIHYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-METHOXYPHENYL)-4-(2-CHLOROETHYL)PIPERAZINE DIHYDROCHLORIDE

There total 8 articles about 1-(2-METHOXYPHENYL)-4-(2-CHLOROETHYL)PIPERAZINE DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-(2-Methoxyphenyl)piperazine (35386-24-4) + 1-Bromo-2-chloroethane (107-04-0) → 1-(2-chloroethyl)-4-(2-methoxyphenyl)piperazine (43091-72-1)

Guidance literature:

With sodium hydroxide; In acetone; at 20 ℃; for 48h;

Reference yield: 73.0%

2-chloro-1-[4-(2-methoxyphenyl)-1-piperazinyl]ethan-1-one (21057-39-6) → 1-(2-chloroethyl)-4-(2-methoxyphenyl)piperazine (43091-72-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 40 ℃; for 0.5h;

DOI:10.1021/jm800928j

Reference yield: 51.0%

1-(2-methoxyphenyl)piperazine hydrochloride (5464-78-8) + 1-Bromo-2-chloroethane (107-04-0) → 1-(2-chloroethyl)-4-(2-methoxyphenyl)piperazine (43091-72-1)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃;

DOI:10.1016/j.bmc.2016.03.044

upstream raw materials:

1-(2-Methoxyphenyl)piperazine

1-Bromo-2-chloroethane

2-chloroethyl tosylate

1-(2-methoxyphenyl)piperazine hydrochloride

Downstream raw materials:

1-[N-(2-methoxycarbonylphenyl)-2-aminoethyl]-4-(2-methoxyphenyl)-piperazine

2-{2-[2-(3-methoxyphenyl)ethyl]phenoxy}ethyl-4-(2'-methoxyphenyl)piperazine

C₂₁H₂₅N₅O

C₂₁H₂₅N₅O

Refernces

• 1、 Ye, Na,Wu, Qianqian,Zhu, Liyuan,Zheng, Longtai,Gao, Bo,Zhen, Xuechu,Zhang, Ao. "Further SAR study on 11-O-substituted aporphine analogues: Identification of highly potent dopamine D3 receptor ligands". experimental part. p. 1999 - 2008. Retrieved 2011/04/26.
• 2、 -. "TREATMENT OF ORGANOPHOSPHATE EXPOSURE WITH TETRAHYDROINDOLONE ARYLPIPERAZINE COMPOUNDS". . . Retrieved 2009/10/30.