4-AMINO-6-METHOXYQUINOLINE

Base Information

• Chemical Name: 4-AMINO-6-METHOXYQUINOLINE
• CAS No.: 6279-51-2
• Molecular Formula: C10H10N2O
• Molecular Weight: 174.202
• Hs Code.: 2933499090
• Mol file: 6279-51-2.mol

Synonyms:Quinoline,4-amino-6-methoxy- (8CI);4-Amino-6-methoxyquinoline;6-Methoxyquinolin-4-ylamine;NSC 11373;6-Methoxyquinolin-4-amine;

Chemical Property of 4-AMINO-6-METHOXYQUINOLINE

Chemical Property:

• Vapor Pressure: 1.17E-05mmHg at 25°C
• Refractive Index: 1.664
• Boiling Point: 369.6 °C at 760 mmHg
• Flash Point: 177.4 °C
• PSA: 48.14000
• Density: 1.217 g/cm³
• LogP: 2.40680

Purity/Quality:

98%min ^*data from raw suppliers

4-amino-6-methoxyquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-AMINO-6-METHOXYQUINOLINE

There total 22 articles about 4-AMINO-6-METHOXYQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

6-methoxy quinoline (5263-87-6) → 6-methoxy-4-aminoquinoline (6279-51-2)

Guidance literature:

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; 9-mesityl-2,7-dimethyl-10-phenylacridin-10-ium tetrafluoroborate; ammonia-glycinate; oxygen; In 1,2-dichloro-ethane; at 23 ℃; for 24h; Irradiation;

Reference yield: 35.0%

6-methoxy-4-nitro-quinoline (917471-40-0) → 6-methoxy-4-aminoquinoline (6279-51-2)

Guidance literature:

With hydrogenchloride; tin; In ethanol; at 70 ℃; for 2h;

DOI:10.1016/j.tetlet.2006.09.140

Reference yield:

6-methoxy quinoline (5263-87-6) → 2-amino-6-methoxy quinoline (119990-33-9) + 6-methoxy-4-aminoquinoline (6279-51-2)

Guidance literature:

With ammonia; potassium amide; potassium nitrate;

DOI:10.1021/jo01220a004

upstream raw materials:

diazomethane

4-amino-quinolin-6-ol

6-methoxy quinoline

4-chloro-6-methoxyquinoline

Downstream raw materials:

N-((4-chlorophenyl)(4-(1-tert-butoxycarbonylpiperazin-4-ylmethyl)phenyl)methyl)-6-methoxy-4-aminoquinoline

4-chloroquinoline

[3-(6-methoxy-quinolin-4-ylcarbamoyl)-cyclohexylmethyl]-carbamic acid tert-butyl ester

4,6-dihydroxyquinoline

Refernces

• 1、 Zhou, Yu,Li, Jian,Liu, Hong,Zhao, Linxiang,Jiang, Hualiang. "An unusual de-nitro reduction of 2-substituted-4-nitroquinolines". . p. 8511 - 8514. Retrieved 2007/10/03.
• 2、 -. "Quinoline derivatives as antibacterials". . . Retrieved 2008/06/13.