2-bromo-3,5-dimethylcyclohexane-2,5-diene-1,4-dione

Base Information

• Chemical Name: 2-bromo-3,5-dimethylcyclohexane-2,5-diene-1,4-dione
• CAS No.: 409316-81-0
• Molecular Formula: C₈H₇BrO₂
• Molecular Weight: 215.046
• Mol file: 409316-81-0.mol

Synonyms:2-bromo-3,5-dimethylcyclohexane-2,5-diene-1,4-dione

Chemical Property of 2-bromo-3,5-dimethylcyclohexane-2,5-diene-1,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-3,5-dimethylcyclohexane-2,5-diene-1,4-dione

There total 4 articles about 2-bromo-3,5-dimethylcyclohexane-2,5-diene-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

p-benzoquinone (106-51-4) → 2-bromo-3,5-dimethylcyclohexane-2,5-diene-1,4-dione (409316-81-0)

Guidance literature:

With sulfuric acid; N,N,N,N-tetraethylammonium tetrafluoroborate; potassium bromide; In acetonitrile; at 23 ℃; Electrolysis;

DOI:10.1016/j.tetlet.2021.153514

Reference yield:

2-bromo-3,5-dimethyl-hydroquinone (409316-82-1) → 2-bromo-3,5-dimethylcyclohexane-2,5-diene-1,4-dione (409316-81-0)

Guidance literature:

With hydrogenchloride; iron(III) sulfate; steam;

DOI:10.1021/ja01209a056

Reference yield:

1,4-dihydroxy-2,6-dimethylbenzene (654-42-2) → 2-bromo-3,5-dimethylcyclohexane-2,5-diene-1,4-dione (409316-81-0)

Guidance literature:

Multi-step reaction with 2 steps

1: glacial acetic acid; bromine

2: Fe₂ (SO₄)3; aqueous HCl; steam

With hydrogenchloride; iron(III) sulfate; steam; bromine; acetic acid;

DOI:10.1021/ja01209a056

upstream raw materials:

2-bromo-3,5-dimethyl-hydroquinone

1,4-dihydroxy-2,6-dimethylbenzene

2,6-dimethyl-1,4-benzoquinone

p-benzoquinone

Downstream raw materials:

2-bromo-3,5-dimethyl-hydroquinone

5-bromo-β,β,2,4-tetramethyl-3,6-dioxo-1,4-cyclohexadiene-1-propanoic acid

(S)-3-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-2-[3-(5-bromo-2,4-dimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-3-methyl-butyrylamino]-propionic acid methyl ester

Refernces