1-(2-AMINOETHYL)-2-IMIDAZOLIDONE

Base Information

• Chemical Name: 1-(2-AMINOETHYL)-2-IMIDAZOLIDONE
• CAS No.: 4432-64-8
• Molecular Formula: C9H8 O2
• Molecular Weight: 148.161
• Mol file: 4432-64-8.mol

Synonyms:Atropaldehyde,b-hydroxy- (4CI);3-Hydroxy-2-phenylpropenal; b-Hydroxy-a-phenylacrolein

Chemical Property of 1-(2-AMINOETHYL)-2-IMIDAZOLIDONE

Chemical Property:

• Boiling Point: 363.1°Cat760mmHg
• Flash Point: 173.4°C
• PSA: 58.36000
• Density: 1.137g/cm³
• LogP: -0.06270

Purity/Quality:

99% ^*data from raw suppliers

3-Hydroxy-2-phenylacrylaldehyde 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 1-(2-AMINOETHYL)-2-IMIDAZOLIDONE

There total 6 articles about 1-(2-AMINOETHYL)-2-IMIDAZOLIDONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

N-styrylmorpholine (36838-59-2) → hydroxymethylenephenylacetaldehyde (4432-64-8)

Guidance literature:

With N-(chloromethylene)-morpholinium chloride; In dichloromethane; at 4 ℃;

DOI:10.1021/jo00181a034

Reference yield:

5-phenyl-1,2,3-triazine (106636-96-8) → 3-Imino-2-phenyl-1-propanal (57623-09-3) + hydroxymethylenephenylacetaldehyde (4432-64-8)

Guidance literature:

With water; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃; for 6h; Reagent/catalyst;

DOI:10.1002/ejoc.201800530

Reference yield:

phenylacetic acid (103-82-2) → hydroxymethylenephenylacetaldehyde (4432-64-8)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃ / 2 h / 85 °C

2: NaOH / ethanol; H₂O / 1 h / Heating

With sodium hydroxide; trichlorophosphate; In ethanol; water;

DOI:10.1016/j.bmc.2005.08.053

upstream raw materials:

2-diazo-malonaldehyde

benzene

N-styrylmorpholine

phenylacetic acid

Downstream raw materials:

3-anilino-2-phenyl-acrylaldehyde

1-methyl-5-phenyl-2(1H)-pyrimidinone

3-chloro-2-phenylpropenal

8-(3-Dec-9-enylcarbonyloxy-6-hydroxyphenyl)-2-phenyl-4,7-diazocta-2,7-dien-1-al

Refernces

• 1、 Pedras, M. Soledade C.,Suchy, Mojmir. "Design, synthesis, and antifungal activity of inhibitors of brassilexin detoxification in the plant pathogenic fungus Leptosphaeria maculans". . p. 714 - 723. Retrieved 2007/10/03.
• 2、 Liepa, Andris J.. "A Synthesis of Hydroxylated Isoflavylium Salts and Their Reduction Products". . p. 2647 - 2655. Retrieved 2007/10/02.