Technology Process of 2,6-diamino-9-<(2,2-dimethyl-1,3-dioxan-5-yl)methoxy>purine
There total 1 articles about 2,6-diamino-9-<(2,2-dimethyl-1,3-dioxan-5-yl)methoxy>purine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 86 percent / diethyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / 16 h / Ambient temperature
2: 79 percent / methylhydrazine / CH2Cl2 / 1 h / 20 °C
3: 77 percent / diisopropylethylamine / bis-(2-methoxy-ethyl) ether / 2.5 h / 100 °C
4: 81 percent / various solvent(s) / 2 h / 120 °C
5: 63 percent / NH3 / methanol / 7.5 h / 110 °C / autoclave
With
ammonia; N-ethyl-N,N-diisopropylamine; triphenylphosphine; methylhydrazine; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; dichloromethane; diethylene glycol dimethyl ether;
DOI:10.1021/jm00163a031
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 78 percent / 80percent acetic acid / 4 h / Ambient temperature
2: 45 percent / 1.) 80percent aq formic acid, 2.) aq NH3 / 1.) 100 deg C, 2 h, 2.) RT, 0.5 h
With
ammonium hydroxide; formic acid; acetic acid;
DOI:10.1021/jm00163a031
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 78 percent / 80percent acetic acid / 4 h / Ambient temperature
2: 45 percent / 1.) 80percent aq formic acid, 2.) aq NH3 / 1.) 100 deg C, 2 h, 2.) RT, 0.5 h
3: 10 percent / 1.) stannic chloride, 2.) phosphoryl chloride / acetonitrile / 1.) RT, 1 h, 2.) 16 h
With
ammonium hydroxide; formic acid; tin(IV) chloride; acetic acid; trichlorophosphate;
In
acetonitrile;
DOI:10.1021/jm00163a031