(3,4-Dimethoxyphenyl)acetyl chloride

Base Information

• Chemical Name: (3,4-Dimethoxyphenyl)acetyl chloride
• CAS No.: 10313-60-7
• Molecular Formula: C10H11ClO3
• Molecular Weight: 214.649
• Hs Code.: 2918990090
• European Community (EC) Number: 628-972-7
• DSSTox Substance ID: DTXSID60394078
• Nikkaji Number: J1.480.133B
• Wikidata: Q82193258
• Mol file: 10313-60-7.mol

Synonyms:(3,4-Dimethoxyphenyl)acetyl chloride;10313-60-7;2-(3,4-dimethoxyphenyl)acetyl Chloride;3,4-dimethoxyphenylacetyl chloride;Benzeneacetyl chloride,3,4-dimethoxy-;Homoveratroylchlorid;homoveratric acid chloride;SCHEMBL76377;3,4-dimethoxyphenylacetylchloride;DTXSID60394078;QBJIMTPENIGDOG-UHFFFAOYSA-N;3,4-dimethoxyphenyl acetylchloride;3,4-di-methoxyphenylacetyl chloride;3,4-dimethoxyphenyl acetyl chloride;STR04364;(3,4-Dimethoxyphenyl)acetylchloride;3,4-Dimethoxy-phenylacetyl chloride;MFCD00009674;AKOS005215788;(3,4-dimethoxy-phenyl)-acetyl chloride;3,4-dimethoxyphenylacetic acid chloride;3,4-Dimethoxy-phenylacetic acid chloride;3,4-Dimethoxybenzeneacetic acid chloride;3,4-dimethoxyphenyl acetic acid chloride;3,4-Dimethoxyphenyl-acetic acid chloride;3.4-dimethoxy-phenylacetic acid chloride;2-(3,4-dimethoxyphenyl)-acetyl chloride;(3,4-Dimethoxyphenyl)acetic acid chloride;(3,4-Dimethoxyphenyl)acetyl chloride, 98%;FT-0604683;F71826;J-000884;F2190-0110

Chemical Property of (3,4-Dimethoxyphenyl)acetyl chloride

Chemical Property:

• Vapor Pressure: 6.52E-05mmHg at 25°C
• Melting Point: 40-43 °C(lit.)
• Refractive Index: n20/D 1.5489(lit.)
• Boiling Point: 344.6 °C at 760 mmHg
• Flash Point: 123.1 °C
• PSA: 35.53000
• Density: 1.2 g/cm³
• LogP: 2.01170
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 214.0396719
• Heavy Atom Count: 14
• Complexity: 196

Purity/Quality:

98%,99%, ^*data from raw suppliers

(3,4-Dimethoxyphenyl)acetyl chloride 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34-36/37
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)CC(=O)Cl)OC
• Uses: 2-(3,4-Dimethoxyphenyl)acetyl chloride is used as a reactant in the cycloaddition reaction with tetramethoxyethylene in the preparation of novel unsymmetrical squaraines. (3,4-Dimethoxyphenyl)acetyl chloride (Homoveratryl chloride) has been used in the preparation of:homo veratryl nitrile (HVN)isomeric naphthalene sulphonyl compounds, 1- and 2-[{2-(3,4-dimethoxyphenyl)ethyl}methylamino] sulphonyl naphthalenes

Technology Process of (3,4-Dimethoxyphenyl)acetyl chloride

There total 18 articles about (3,4-Dimethoxyphenyl)acetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(3,4-Dimethoxyphenyl)acetic acid (93-40-3) → 3,4-dimethoxyphenylacetyl chloride (10313-60-7)

Guidance literature:

With thionyl chloride; In dichloromethane;

DOI:10.1016/j.bmcl.2007.09.036

Reference yield:

(3,4-Dimethoxyphenyl)acetic acid (93-40-3) + 2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → N-(3,4-dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)acetamide (139-76-4) + 3,4-dimethoxyphenylacetyl chloride (10313-60-7)

Guidance literature:

With sodium hydroxide; thionyl chloride; In methanol; dichloromethane; chloroform;

Reference yield:

2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → 3,4-dimethoxyphenylacetyl chloride (10313-60-7)

Guidance literature:

With triethylamine; In chloroform;

upstream raw materials:

(3,4-Dimethoxyphenyl)acetic acid

3,4-dihydroxyphenylacetic acid diacetate

2-diazo-1-(3,4-dimethoxyphenyl)ethan-1-one

Veratric acid

Downstream raw materials:

1-chloro-3-(3,4-dimethoxy-phenyl)-acetone

3-<3,4-dimethoxyphenyl>-2-oxo propanol

1-Brom-3-(3,4-dimethoxyphenyl)-2-propanon

1-acetoxy-3-(3,4-dimethoxy-phenyl)-acetone

Refernces

• 1、 Shcherbakova, I. V.,Ukhin, L. Yu.,Komissarov, V. N.,Kuznetsov, E. V.,Polyakov, A. V.,et al.. "2-Benzopyrilium Salts. 30. Synthesis and Properties of 2-Benzopyrilium Salts with the 2,6-Di-t-butylphenyl Substituent in Position 3". . p. 824 - 829. Retrieved 1987.
• 2、 Bisht, Narendra,Babu, Srinivasarao Arulananda. "Synthesis of ortho-arylated/benzylated arylacetamide derivatives: Pd(OAc)2-catalyzed bidentate ligand-aided arylation and benzylation of the γ-C[sbnd]H bond of arylacetamides". . p. 5886 - 5897. Retrieved 2016.
• 3、 Dyke,S.F. et al.. "-". . p. 3495 - 3502. Retrieved 1971.
• 4、 Tambar, Uttam K.,Ebner, David C.,Stoltz, Brian M.. "A convergent and enantioselective synthesis of (+)-amurensinine via selective C-H and C-C bond insertion reactions". . p. 11752 - 11753. Retrieved 2006.
• 5、 Higginson, Cody J.,Malollari, Katerina G.,Xu, Yunqi,Kelleghan, Andrew V.,Ricapito, Nicole G.,Messersmith, Phillip B.. "Bioinspired Design Provides High-Strength Benzoxazine Structural Adhesives". . p. 12271 - 12279. Retrieved 2019.
• 6、 Cui, Dongmei,Gao, Mingjie,Li, Jinjie,Li, Shoujie,Nian, Xin,Zhang, Chen,Zhang, Liyu,Zhao, Changqi. "Design, synthesis, biological evaluation and silico prediction of novel sinomenine derivatives". . . Retrieved 2021/06/25.
• 7、 Fang, Hai-Lian,He, Jie-Ling,Li, Wei-Yi,Liu, Shan-Shan,Ni, Wei-Wei,Pan, Xing-Ming,Xiao, Zhu-Ping,Ye, Ya-Xi,Yi, Juan,Zhou, Mi,Zhou, Tian-Li,Zhu, Hai-Liang. "N-monoarylacetothioureas as potent urease inhibitors: synthesis, SAR, and biological evaluation". . p. 404 - 413. Retrieved 2020/01/03.