α,α-diphenyl-2-benzofuranmethanol

Base Information

• Chemical Name: α,α-diphenyl-2-benzofuranmethanol
• CAS No.: 3199-62-0
• Molecular Formula: C₂₁H₁₆O₂
• Molecular Weight: 300.357
• Mol file: 3199-62-0.mol

Synonyms:α,α-diphenyl-2-benzofuranmethanol

Chemical Property of α,α-diphenyl-2-benzofuranmethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α,α-diphenyl-2-benzofuranmethanol

There total 7 articles about α,α-diphenyl-2-benzofuranmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-(3-hydroxy-3,3-diphenylprop-1-yn-1-yl)phenol (343309-52-4) → 1,1-Diphenyl-3-<2-hydroxy-phenyl>-prop-2-en-1-ol (61714-10-1) + α,α-diphenyl-2-benzofuranmethanol (3199-62-0)

Guidance literature:

With bis(triphenylphosphine)dichlorocobalt(II); 5,5'-dimethyl-2,2'-bipyridine; (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; In ethanol; at 28 - 32 ℃; for 6h; Reagent/catalyst; Solvent; Time; Mechanism; Catalytic behavior; Inert atmosphere; Irradiation;

DOI:10.1002/adsc.202100221

Reference yield: 87.0%

1-benzofurane (271-89-6) + benzophenone (119-61-9) → α,α-diphenyl-2-benzofuranmethanol (3199-62-0)

Guidance literature:

1-benzofurane; With Bu₄MgLi₂; In tetrahydrofuran; at 20 ℃; for 2h;

benzophenone; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.tetlet.2005.09.066

Reference yield:

2-Iodophenol (533-58-4) + 1,1-diphenyl-2-propyn-1-ol (3923-52-2) → α,α-diphenyl-2-benzofuranmethanol (3199-62-0)

Guidance literature:

With C₅₃H₄₃IN₃P₂Pd⁽¹⁺⁾*I^(1-); potassium carbonate; In dimethyl sulfoxide; at 90 ℃; for 2h;

DOI:10.1039/d0dt02918a

upstream raw materials:

2-benzoylbenzofuran

diethyl ether

1-benzofurane

benzophenone

Downstream raw materials:

(2-benzofuryl)diphenylmethane

Refernces

• 1、 Ding, Hai-Xin,He, Yong-Qin,Song, Xian-Rong,Tian, Wan-Fa,Wang, Mei,Xiao, Qiang,Zhou, Zhao-Zhao,Zhu, Yao. "Dual Cobalt and Photoredox Catalysis Enabled Redox-Neutral Annulation of 2-Propynolphenols". . p. 3372 - 3377. Retrieved 2021.
• 2、 Inamoto, Kiyofumi,Okawa, Hitomi,Taneda, Hiroshi,Sato, Maomi,Hirono, Yutaro,Yonemoto, Misato,Kikkawa, Shoko,Kondo, Yoshinori. "Organocatalytic deprotonative functionalization of C(sp2)-H and C(sp3)-H bonds using in situ generated onium amide bases". supporting information. p. 9771 - 9773,3. Retrieved 2020/08/31.