Technology Process of (R)-N-benzyloxycarbonyl-2-(2-oxo-2-p-tolylethyl)piperidine
There total 8 articles about (R)-N-benzyloxycarbonyl-2-(2-oxo-2-p-tolylethyl)piperidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
C20H25N3O; trifluoroacetic acid;
In
tetrahydrofuran;
at 25 ℃;
for 120h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1002/adsc.201100282
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 °C / Inert atmosphere
1.2: -78 °C / Inert atmosphere
2.1: toluene / Inert atmosphere; Reflux
3.1: C20H25N3O; trifluoroacetic acid / tetrahydrofuran / 120 h / 25 °C / Inert atmosphere
With
oxalyl dichloride; C20H25N3O; dimethyl sulfoxide; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; toluene;
2.1: Wittig reaction / 3.1: Michael condensation;
DOI:10.1002/adsc.201100282
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C / Inert atmosphere
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 °C / Inert atmosphere
2.2: -78 °C / Inert atmosphere
3.1: toluene / Inert atmosphere; Reflux
4.1: C20H25N3O; trifluoroacetic acid / tetrahydrofuran / 120 h / 25 °C / Inert atmosphere
With
oxalyl dichloride; C20H25N3O; tetrabutyl ammonium fluoride; dimethyl sulfoxide; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; toluene;
3.1: Wittig reaction / 4.1: Michael condensation;
DOI:10.1002/adsc.201100282