2,3,5,6-TETRAFLUORONITROBENZENE

Base Information

• Chemical Name: 2,3,5,6-TETRAFLUORONITROBENZENE
• CAS No.: 6257-03-0
• Molecular Formula: C6HF4NO2
• Molecular Weight: 195.073
• Hs Code.: 2904909090
• Mol file: 6257-03-0.mol

Synonyms:2,3,5,6-Tetrafluoronitrobenzene;

Chemical Property of 2,3,5,6-TETRAFLUORONITROBENZENE

Chemical Property:

• Vapor Pressure: 0.142mmHg at 25°C
• Refractive Index: 1.467
• Boiling Point: 223.6 °C at 760 mmHg
• Flash Point: 89 °C
• PSA: 45.82000
• Density: 1.651 g/cm³
• LogP: 2.67440
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,2,4,5-Tetrafluoro-3-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,2,4,5-Tetrafluoro-3-nitrobenzene is derived from the electrochemical reduction of 1,2,4,5-tetrafluoro-3,6-dinitrobenzene in DMF containing proton donors

Technology Process of 2,3,5,6-TETRAFLUORONITROBENZENE

There total 12 articles about 2,3,5,6-TETRAFLUORONITROBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

triethylsilane (617-86-7) + pentafluoronitrobenzen (880-78-4) → triethylsilyl fluoride (358-43-0) + 2,3,5,6-tetrafluoro-4-nitrobenzene (6257-03-0)

Guidance literature:

With dmap; (1,3-bis(2,4,6-trimethylphenyl)imidazolin-2-ylidene)AuH; In dichloromethane; at 40 ℃; for 12h; Concentration; Solvent; Reagent/catalyst; Inert atmosphere;

DOI:10.1021/ja305204y

Reference yield: 77.0%

pentafluoronitrobenzen (880-78-4) → 2,3,5,6-tetrafluoro-4-nitrobenzene (6257-03-0) + 2,3,4,5-tetrafluoro-1-nitrobenzene (5580-79-0)

Guidance literature:

With tetrabutylammonium triphenyldifluorosilicate; HSiPh₃; In tetrahydrofuran; benzene-d6; at 20 ℃; for 20h; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201708003

Reference yield: 61.0%

2,3,5,6-tetrafluoroaniline (700-17-4) → 2,3,5,6-tetrafluoro-4-nitrobenzene (6257-03-0)

Guidance literature:

With water; fluorine; In acetonitrile; at 20 ℃; for 5h; Inert atmosphere; Flow reactor;

DOI:10.1002/cssc.201100423

upstream raw materials:

1,2,4,5-Tetrafluorobenzene

2,3,5,6-tetrafluoronitrosobenzene

1,2,4,5-tetrafluoro-3,6-dinitrobenzene

2,3,5,6-tetrafluoroaniline

Downstream raw materials:

3,4,6-trifluoro-N,N-dimethyl-2-nitroaniline

2,5-difluoro-N₁,N₁,N₄,N₄-tetramethyl-3-nitrobenzene-1,4-diamine

2,4,5-trifluoro-6-nitrobiphenyl

1-bromo-2,3,5,6-tetrafluoro-4-nitrobenzene

Refernces

• 1、 Matsunami, Asuka,Kuwata, Shigeki,Kayaki, Yoshihito. "Hydrodefluorination of Fluoroarenes Using Hydrogen Transfer Catalysts with a Bifunctional Iridium/NH Moiety". . p. 5181 - 5185. Retrieved 2016/08/18.
• 2、 McPake, Christopher B.,Murray, Christopher B.,Sandford, Graham. "Sequential continuous flow processes for the oxidation of amines and azides by using HOF·MeCN". experimental part. p. 312 - 319. Retrieved 2012/06/15.