L-NORVALINE T-BUTYL ESTER

Base Information

• Chemical Name: L-NORVALINE T-BUTYL ESTER
• CAS No.: 15911-75-8
• Molecular Formula: C9H19NO2
• Molecular Weight: 173.255
• Hs Code.: 2922499990
• DSSTox Substance ID: DTXSID20477290
• Wikidata: Q82309691
• Mol file: 15911-75-8.mol

Synonyms:Norvaline,tert-butyl ester, L- (7CI,8CI);Norvaline tert-butyl ester;

Chemical Property of L-NORVALINE T-BUTYL ESTER

Chemical Property:

• Boiling Point: 201.7 °C at 760 mmHg
• Flash Point: 72.1 °C
• PSA: 52.32000
• Density: 0.936 g/cm³
• LogP: 2.15580
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 173.141578849
• Heavy Atom Count: 12
• Complexity: 149

Purity/Quality:

98%Min ^*data from raw suppliers

L-NORVALINE T-BUTYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCC(C(=O)OC(C)(C)C)N
• Isomeric SMILES: CCC[C@@H](C(=O)OC(C)(C)C)N

Technology Process of L-NORVALINE T-BUTYL ESTER

There total 4 articles about L-NORVALINE T-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

benzyl (S)-1-(tert-butoxycarbonyl)butylcarbamate (925240-84-2) → (S)-2-aminopentanoic acid tert-butyl ester (15911-75-8,158741-16-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 8h;

DOI:10.1016/j.bmc.2006.10.044

Reference yield: 0.9%

(2S)-aminopentanoic acid tert-butyl ester hydrochloride → (S)-2-aminopentanoic acid tert-butyl ester (15911-75-8,158741-16-3)

Guidance literature:

With sodium carbonate; sodium chloride; In water;

Reference yield:

acetic acid tert-butyl ester (540-88-5) + L-Norvaline (6600-40-4,498-18-0) → (S)-2-aminopentanoic acid tert-butyl ester (15911-75-8,158741-16-3)

Guidance literature:

With perchloric acid; for 48h; Ambient temperature;

DOI:10.1021/jm00046a014

upstream raw materials:

acetic acid tert-butyl ester

L-Norvaline

benzyl (S)-1-(tert-butoxycarbonyl)butylcarbamate

Z-L-norvaline

Downstream raw materials:

(S)-2-((S)-4-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-pentanoic acid tert-butyl ester

trans-5-[((S)-1-tert-butoxycarbonylbutyl)carbamoyl]-3-(7-methoxy-2-phenylquinolin-4-yloxy)cyclopent-1-enecarboxylic acid methyl ester

(S)-2-((S)-4-tert-Butoxycarbonyl-4-{4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyrylamino)-pentanoic acid tert-butyl ester

C₂₄H₃₅F₂N₅O

Refernces

• 1、 -. "Macrocyclic Modulators of the Ghrelin Receptor". Paragraph 0574; 0575. . Retrieved 2018/05/03.
• 2、 Bisset, Graham M. F.,Bavetsias, Vassilios,Thornton, Timothy J.,Pawelczak, Krzysztof,Calvert, A. Hilary,et al.. "The Synthesis and Thymidylate Synthase Inhibitory Activity of L-γ-L-Linked Dipeptide and L-γ-Amide Analogues of 2-Desamino-2-methyl-N10-propargyl-5,8-dideazafolic Acid (ICI 198583)". . p. 3294 - 3302. Retrieved 2007/10/02.