5-Methylpyridine-2-boronic acid

Base Information

• Chemical Name: 5-Methylpyridine-2-boronic acid
• CAS No.: 372963-49-0
• Molecular Formula: C6H8BNO2
• Molecular Weight: 136.946
• Hs Code.: 2933399990
• European Community (EC) Number: 689-059-7
• DSSTox Substance ID: DTXSID80376412
• Wikidata: Q72496519
• Mol file: 372963-49-0.mol

Synonyms:372963-49-0;5-Methylpyridine-2-boronic acid;(5-methylpyridin-2-yl)boronic Acid;5-Methyl-2-pyridineboronic acid;5-Methylpyridin-2-ylboronic acid;BORONIC ACID, (5-METHYL-2-PYRIDINYL)-;MFCD00674179;5-Picoline-2-boronic acid;2-cyanophenylboronic?acid;SCHEMBL200776;DTXSID80376412;(5-methylpyridin-2-yl)boronicAcid;(5-methyl-2-pyridinyl)boronic acid;AKOS006345709;AB06946;CS-W018321;AC-16667;AS-46748;5-methylpyridine-2-boronic acid, AldrichCPR;AM20051125;FT-0604824;EN300-155098;F10369;A823589;J-517769

Chemical Property of 5-Methylpyridine-2-boronic acid

Chemical Property:

• Vapor Pressure: 0.000196mmHg at 25°C
• Melting Point: 86-90 °C
• Refractive Index: 1.527
• Boiling Point: 314.576 °C at 760 mmHg
• PKA: 8.11±0.53(Predicted)
• Flash Point: 144.051 °C
• PSA: 53.35000
• Density: 1.18 g/cm³
• LogP: -0.93020
• Storage Temp.: Store below -20
• Water Solubility.: Slightly soluble in water.
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 137.0648087
• Heavy Atom Count: 10
• Complexity: 110

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-methylpyridine-2-boronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-41-37/38
• Safety Statements: 26-36/37/39-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: B(C1=NC=C(C=C1)C)(O)O
• Uses: 5-Methylpyridine-2-boronic acid is used as an organic chemical synthesis intermediate.

Technology Process of 5-Methylpyridine-2-boronic acid

There total 1 articles about 5-Methylpyridine-2-boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (5-methylpyridin-2-yl)boronic acid (372963-49-0)

Guidance literature:

Reference yield: 81.0%

(5-methylpyridin-2-yl)boronic acid (372963-49-0) + (3-bromophenyl)trimethylsilane (17878-47-6) → 4-methyl-2-(3-trimethylsilylphenyl)pyridine

Guidance literature:

With palladium diacetate; potassium carbonate; triphenylphosphine; In methanol; acetonitrile; at 50 ℃;

Reference yield: 11.0%

(5-methylpyridin-2-yl)boronic acid (372963-49-0) + 5-[4-bromo-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one → 5-[4-(5-methylpyridin-2-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; caesium carbonate; copper(l) chloride; In N,N-dimethyl-formamide; at 100 ℃; Inert atmosphere;

Downstream raw materials:

4-methyl-2-({1-[4-(5-methylpyridin-2-yl)benzoyl]piperidin-4-yl}methyl)-N-(2,2,2-trifluoroethyl)-2H-indazole-5-carboxamide

Refernces