2',3'-Di-O-acetyl-5'-S-(4-chlorophenyl)-5'-thioadenosine

Base Information

• Chemical Name: 2',3'-Di-O-acetyl-5'-S-(4-chlorophenyl)-5'-thioadenosine
• CAS No.: 153920-21-9
• Molecular Formula: C₂₀H₂₀ClN₅O₅S
• Molecular Weight: 477.928
• Mol file: 153920-21-9.mol

Synonyms:2',3'-Di-O-acetyl-5'-S-(4-chlorophenyl)-5'-thioadenosine

Chemical Property of 2',3'-Di-O-acetyl-5'-S-(4-chlorophenyl)-5'-thioadenosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2',3'-Di-O-acetyl-5'-S-(4-chlorophenyl)-5'-thioadenosine

There total 3 articles about 2',3'-Di-O-acetyl-5'-S-(4-chlorophenyl)-5'-thioadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

acetic anhydride (108-24-7) + 5'-S-(4-Chlorophenyl)-5'-thioadenosine (153920-20-8) → 2',3'-Di-O-acetyl-5'-S-(4-chlorophenyl)-5'-thioadenosine (153920-21-9)

Guidance literature:

With pyridine; at 0 ℃; for 7h;

DOI:10.1021/jo00082a010

Reference yield:

p-Chlorothiophenol (106-54-7) → 2',3'-Di-O-acetyl-5'-S-(4-chlorophenyl)-5'-thioadenosine (153920-21-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / NaH / dimethylformamide

2: 97 percent / pyridine / 7 h / 0 °C

With pyridine; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/jo00082a010

Reference yield:

5'-deoxy-5'-chloroadenosine (892-48-8) → 2',3'-Di-O-acetyl-5'-S-(4-chlorophenyl)-5'-thioadenosine (153920-21-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / NaH / dimethylformamide

2: 97 percent / pyridine / 7 h / 0 °C

With pyridine; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/jo00082a010

upstream raw materials:

acetic anhydride

5'-S-(4-Chlorophenyl)-5'-thioadenosine

p-Chlorothiophenol

5'-deoxy-5'-chloroadenosine

Refernces