4-AMINO-5-BROMO NICOTINIC ACID

Base Information

• Chemical Name: 4-AMINO-5-BROMO NICOTINIC ACID
• CAS No.: 52834-08-9
• Molecular Formula: C₆H₅BrN₂O₂
• Molecular Weight: 217.022
• Hs Code.: 2933399090
• Mol file: 52834-08-9.mol

Synonyms:4-Amino-5-bromo nicotinic acid;

Chemical Property of 4-AMINO-5-BROMO NICOTINIC ACID

Chemical Property:

• Vapor Pressure: 5.3E-07mmHg at 25°C
• Refractive Index: 1.685
• Boiling Point: 396.6 °C at 760 mmHg
• Flash Point: 193.7 °C
• PSA: 76.21000
• Density: 1.909 g/cm³
• LogP: 1.70570
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Amino-5-bromonicotinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-AMINO-5-BROMO NICOTINIC ACID

There total 7 articles about 4-AMINO-5-BROMO NICOTINIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

4-aminonicotinic acid (7418-65-7) → 4-amino-5-bromonicotinic acid (52834-08-9)

Guidance literature:

With bromine; acetic acid; In water; at 0 - 20 ℃;

Reference yield:

C9H14O3NC6H5 (41276-30-6) → 4-amino-5-bromonicotinic acid (52834-08-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogen / acetonitrile / 4 h / 45 - 50 °C / 2250.23 - 3000.3 Torr / Autoclave

2.1: dihydrogen peroxide; hydrogen bromide / dichloromethane / 5 h / 40 - 45 °C

3.1: ammonium hydroxide / tetrahydrofuran / 4 h / 40 - 45 °C

3.2: 2 h / 20 - 35 °C

With ammonium hydroxide; hydrogen bromide; hydrogen; dihydrogen peroxide; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield:

C9H14O3NC6H5 (41276-30-6) → 4-amino-5-bromonicotinic acid (52834-08-9) + 4-aminonicotinic acid (7418-65-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogen / acetonitrile / 4 h / 45 - 50 °C / 2250.23 - 3000.3 Torr / Autoclave

2.1: dihydrogen peroxide; hydrogen bromide / dichloromethane / 5 h / 40 - 45 °C

2.2: 4 h / 40 - 45 °C

2.3: 2 h / 20 - 35 °C

With hydrogen bromide; hydrogen; dihydrogen peroxide; In dichloromethane; acetonitrile;

upstream raw materials:

4-aminonicotinic acid

4-piperidone-3-carboxylic acid ethyl ester

C₉H₁₄O₃NC₆H₅

Refernces

• 1、 -. "Pyrido-pyrimidines, its preparation and use". Paragraph 0138; 0139. . Retrieved 2017/06/21.
• 2、 -. "FUSED PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF HIV". Paragraph 0215. . Retrieved 2016/07/27.