6-Bromo-2-methoxy-3-nitropyridine

Base Information

• Chemical Name: 6-Bromo-2-methoxy-3-nitropyridine
• CAS No.: 58819-77-5
• Molecular Formula: C6H5BrN2O3
• Molecular Weight: 233.021
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID80483296
• Wikidata: Q82320485
• Mol file: 58819-77-5.mol

Synonyms:6-Bromo-2-methoxy-3-nitropyridine;58819-77-5;6-Bromo-2-methoxy-3-nitro-pyridine;SCHEMBL1029176;DTXSID80483296;OMOZIEOLBBCAFW-UHFFFAOYSA-N;MFCD00234158;AKOS015891755;AB05164;CS-0094586;FT-0648642;D75592

Chemical Property of 6-Bromo-2-methoxy-3-nitropyridine

Chemical Property:

• Vapor Pressure: 0.006mmHg at 25°C
• Melting Point: 92 °C(Solv: benzene (71-43-2))
• Refractive Index: 1.587
• Boiling Point: 281.982 °C at 760 mmHg
• PKA: -5.08±0.10(Predicted)
• Flash Point: 124.339 °C
• PSA: 67.94000
• Density: 1.73 g/cm³
• LogP: 2.28410
• Storage Temp.: 2-8°C
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 231.94835
• Heavy Atom Count: 12
• Complexity: 173

Purity/Quality:

98%min ^*data from raw suppliers

6-Bromo-2-methoxy-3-nitro-pyridine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi:
• Statements: 20/21/22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=CC(=N1)Br)[N+](=O)[O-]

Technology Process of 6-Bromo-2-methoxy-3-nitropyridine

There total 3 articles about 6-Bromo-2-methoxy-3-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2,6-dibromo-3-nitropyridine (55304-80-8) + sodium methylate (124-41-4) → 6-bromo-2-methoxy-3-nitropyridine (58819-77-5)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 3h; Cooling with ice;

Reference yield: 60.0%

2,6-dibromo-3-nitropyridine (55304-80-8) → 6-bromo-2-methoxy-3-nitropyridine (58819-77-5)

Guidance literature:

With sodium methylate; In tetrahydrofuran; at 0 - 5 ℃; for 3h;

Reference yield:

→ 6-bromo-2-methoxy-3-nitropyridine (58819-77-5)

Guidance literature:

2-Methoxy-6-brom-pyridin in H2SO4, Salpetersaeure;

upstream raw materials:

2,6-dibromo-3-nitropyridine

sodium methylate

Downstream raw materials:

6-(2-(benzyl-propyl-amino)-ethoxy)-2-methoxy-pyridin-3-ylamine

6-(1-benzyl-pyrrolidin-3-yloxy)-2-methoxy-pyridin-3-ylamine

benzyl-[2-(6-methoxy-5-nitro-pyridin-2-yloxy)-ethyl]-propyl-amine

6-(1-benzyl-pyrrolidin-3-yloxy)-2-methoxy-3-nitro-pyridine

Refernces

• 1、 -. "Epidermal growth factor receptor inhibitor and preparation and application thereof". Paragraph 0113; 0116-0118. . Retrieved 2020/01/12.
• 2、 Martani,Fravolini,Schiaffella,Orzalesi,Selleri,Volpato. "Pyridine derivatives with potential antiviral activity". . p. 590 - 597. Retrieved 2007/10/08.