2-Chloro-4-Bromo-3-Picoline

Base Information

• Chemical Name: 2-Chloro-4-Bromo-3-Picoline
• CAS No.: 128071-86-3
• Molecular Formula: C6H5BrClN
• Molecular Weight: 206.469
• Hs Code.: 2933399090
• Mol file: 128071-86-3.mol

Synonyms:bromo-4 chloro-2 methyl-3 pyridine;4-Bromo-2-chloro-3-picoline;2-CHLORO-4-BROMO-3-PICOLINE;4-BROMO-2-CHLOROPICOLINE;

Chemical Property of 2-Chloro-4-Bromo-3-Picoline

Chemical Property:

• Refractive Index: 1.571
• Boiling Point: 249.746 °C at 760 mmHg
• Flash Point: 104.843 °C
• PSA: 12.89000
• Density: 1.625g/cm³
• LogP: 2.80590
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

4-Bromo-2-chloro-3-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-4-Bromo-3-Picoline

There total 2 articles about 2-Chloro-4-Bromo-3-Picoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.2%

2-chloro-4-bromopyridine (73583-37-6) + methyl iodide (74-88-4) → bromo-4 chloro-2 methyl-3 pyridine (128071-86-3)

Guidance literature:

2-chloro-4-bromopyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -70 ℃; for 1h;

methyl iodide; In tetrahydrofuran; at -70 ℃; for 0.833333h;

Reference yield:

3-bromo-2-chloropyridine (52200-48-3) + methyl iodide (74-88-4) → bromo-4 chloro-2 methyl-3 pyridine (128071-86-3)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1016/0022-328X(90)80210-Q

Reference yield: 67.0%

methyl 3-(4-ethynylphenyl)propanoate (1068471-18-0) + bromo-4 chloro-2 methyl-3 pyridine (128071-86-3) → methyl 3-(4-((2-chloro-3-methylpyridin-4-yl)ethynyl)phenyl)-propanoate (1334589-85-3)

Guidance literature:

With copper(l) iodide; sodium tetrachloropalladate(II); N,N,N,N,-tetramethylethylenediamine; di‐tert‐butyl‐(1‐phenylindol‐2‐yl)phosphane; In water; at 80 ℃; Inert atmosphere;

DOI:10.1021/jm2005699

upstream raw materials:

3-bromo-2-chloropyridine

methyl iodide

2-chloro-4-bromopyridine

Downstream raw materials:

methyl 3-(4-((2-chloro-3-methylpyridin-4-yl)ethynyl)phenyl)-propanoate

3-(4-((2-chloro-3-methylpyridin-4-yl)ethynyl)phenyl)propanoic acid

Refernces

• 1、 Christiansen, Elisabeth,Urban, Christian,Grundmann, Manuel,Due-Hansen, Maria E.,Hagesaether, Ellen,Schmidt, Johannes,Pardo, Leonardo,Ullrich, Susanne,Kostenis, Evi,Kassack, Matthias,Ulven, Trond. "Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties". scheme or table. p. 6691 - 6703. Retrieved 2011/12/02.