2-CHLORO-3-IODO-5-PICOLINE

Base Information

• Chemical Name: 2-CHLORO-3-IODO-5-PICOLINE
• CAS No.: 59782-91-1
• Molecular Formula: C6H5ClIN
• Molecular Weight: 253.46807
• Hs Code.: 2933399090
• Mol file: 59782-91-1.mol

Synonyms:6-Chloro-5-iodo-3-methylpyridine;

Chemical Property of 2-CHLORO-3-IODO-5-PICOLINE

Chemical Property:

• Vapor Pressure: 0.00522mmHg at 25°C
• Melting Point: 61-63 °C(Solv: ethyl ether (60-29-7))
• Refractive Index: 1.624
• Boiling Point: 284.1 °C at 760 mmHg
• PKA: -0.31±0.10(Predicted)
• Flash Point: 125.6 °C
• PSA: 12.89000
• Density: 1.906 g/cm³
• LogP: 2.64800
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Chloro-3-iodo-5-methylpyridine Aldrich ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-3-IODO-5-PICOLINE

There total 4 articles about 2-CHLORO-3-IODO-5-PICOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-Amino-2-chloro-5-methylpyridine (34552-13-1) → 2-chloro-3-iodo-5-methylpyridine (59782-91-1)

Guidance literature:

3-Amino-2-chloro-5-methylpyridine; With hydrogenchloride; sodium nitrite; In water; at -15 - -10 ℃; for 0.25h;

With potassium iodide; In water; at -5 - 20 ℃; for 3.5h;

DOI:10.1016/j.ejmech.2015.01.034

Reference yield: 72.0%

2-amino-3-iodo-5-methylpyridine (211308-79-1) → 2-chloro-3-iodo-5-methylpyridine (59782-91-1)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; at -10 - 20 ℃; for 2.33333h;

DOI:10.1016/j.ejmech.2015.01.034

Reference yield:

(5-methyl-pyridin-2-yl)amine (1603-41-4) → 2-chloro-3-iodo-5-methylpyridine (59782-91-1)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine; silver(II) sulfate / ethanol / 24 h / 20 °C / Inert atmosphere

2: hydrogenchloride; sodium nitrite / water / 2.33 h / -10 - 20 °C

With hydrogenchloride; silver(II) sulfate; iodine; sodium nitrite; In ethanol; water;

DOI:10.1016/j.ejmech.2015.01.034

upstream raw materials:

2-amino-3-iodo-5-methylpyridine

3-Amino-2-chloro-5-methylpyridine

(5-methyl-pyridin-2-yl)amine

Downstream raw materials:

3-bromomethyl-6-chloro-5-iodopyridine

2-chloro-5-methyl-3-phenylpyridine

6-chloro-5-phenylpyridin-3-ylmethyl bromide

Refernces