2-CHLORO-3,5-DIAMINOPYRIDINE

Base Information

• Chemical Name: 2-CHLORO-3,5-DIAMINOPYRIDINE
• CAS No.: 5632-81-5
• Molecular Formula: C5H6ClN3
• Molecular Weight: 143.576
• Hs Code.: 2933399090
• Mol file: 5632-81-5.mol

Synonyms:Pyridine,3,5-diamino-2-chloro- (7CI,8CI);

Chemical Property of 2-CHLORO-3,5-DIAMINOPYRIDINE

Chemical Property:

• Vapor Pressure: 1E-06mmHg at 25°C
• Melting Point: 101-103 °C
• Refractive Index: 1.685
• Boiling Point: 403.6 °C at 760 mmHg
• PKA: 3.04±0.10(Predicted)
• Flash Point: 197.9 °C
• PSA: 64.93000
• Density: 1.447g/cm³
• LogP: 2.06180
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%Min ^*data from raw suppliers

3,5-Diamino-2-chloropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-3,5-DIAMINOPYRIDINE

There total 5 articles about 2-CHLORO-3,5-DIAMINOPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloro-3,5-dinitropyridine (2578-45-2) → 3,5-diamino-2-chloropyridine (5632-81-5)

Guidance literature:

With palladium on carbon; hydrogen; In methanol; at 20 ℃; for 48h;

DOI:10.1002/cbic.201000177

Reference yield:

2-chloro-3,5-dinitropyridine (2578-45-2) + iron (7439-89-6) → 3,5-diamino-2-chloropyridine (5632-81-5)

Guidance literature:

With hydrogenchloride; In ethanol; water;

Reference yield:

5-nitro-2-hydroxypyridine (5418-51-9) → 3,5-diamino-2-chloropyridine (5632-81-5)

Guidance literature:

Multi-step reaction with 3 steps

1: nitric acid; sulfuric acid / 6 h / 80 °C

2: trichlorophosphate / N,N-dimethyl-formamide / 4 h / 100 °C / Cooling with ice

3: hydrogenchloride; tin / 1.5 h / 70 °C / Cooling with ice

With hydrogenchloride; tin; sulfuric acid; nitric acid; trichlorophosphate; In N,N-dimethyl-formamide;

DOI:10.1002/chem.201903643

upstream raw materials:

2-chloro-3,5-dinitropyridine

iron

5-nitro-2-hydroxypyridine

2-hydroxy-3,5-dinitropyridine

Downstream raw materials:

C₂₀H₃₁N₇O₃

MC₀₆₉A

C₃₈H₆₁N₇O₁₀

C₄₀H₆₃N₇O₁₁

Refernces

• 1、 Hirota, Junko,Usui, Kazuteru,Fuchi, Yasufumi,Sakuma, Masaomi,Matsumoto, Shota,Hagihara, Ryusuke,Karasawa, Satoru. "Fluorescence Properties and Exciplex Formation of Emissive Naphthyridine Derivatives: Application as Sensors for Amines". . p. 14943 - 14952. Retrieved 2019/11/13.
• 2、 -. "Pyridonecarboxylic acid derivatives or their salts and antibacterial agent comprising the same as the active ingredient". . . Retrieved 2008/06/13.