2,4-Dichloro-6-methylpyridine

Base Information

• Chemical Name: 2,4-Dichloro-6-methylpyridine
• CAS No.: 42779-56-6
• Molecular Formula: C6H5Cl2N
• Molecular Weight: 162.018
• Hs Code.: 2933399090
• European Community (EC) Number: 640-599-1
• DSSTox Substance ID: DTXSID50474777
• Wikidata: Q72466906
• Mol file: 42779-56-6.mol

Synonyms:2,4-dichloro-6-methylpyridine;42779-56-6;2,4-Dichloro-6-picoline;2,4-dichloro-6-methyl-pyridine;MFCD08669834;Dichloro-6-methylpyridine;D0RI6L;M-3000;SCHEMBL380662;2-Methyl-4,6-dichloropyridine;DTXSID50474777;WUGTXQVNSRFDNV-UHFFFAOYSA-N;Pyridine,2,4-dichloro-6-methyl-;Pyridine, 2,4-dichloro-6-methyl-;BBL104289;STL558539;AKOS002682472;AB46092;CS-W003538;FD-0748;AC-23236;SY015448;2,4-Dichloro-6-methylpyridine, AldrichCPR;AM20061769;FT-0659771;EN300-97521;A18769;J-507159

Chemical Property of 2,4-Dichloro-6-methylpyridine

Chemical Property:

• Vapor Pressure: 0.285mmHg at 25°C
• Refractive Index: 1.547
• Boiling Point: 209.993 °C at 760 mmHg
• PKA: 1.15±0.10(Predicted)
• Flash Point: 100.483 °C
• PSA: 12.89000
• Density: 1.319 g/cm³
• LogP: 2.69680
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility.: Slightly soluble in water.
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 160.9799046
• Heavy Atom Count: 9
• Complexity: 97.1

Purity/Quality:

99.5% ^*data from raw suppliers

2,4-Dichloro-6-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CC(=N1)Cl)Cl
• Uses: It is an important raw material and intermediate used in organic synthesis agrochemical, pharmaceutical and dyestuff field.

Technology Process of 2,4-Dichloro-6-methylpyridine

There total 7 articles about 2,4-Dichloro-6-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2,4-dihydroxy-6-methylpyridine (3749-51-7) → 2,4-dichloro-6-methyl-pyridine (42779-56-6)

Guidance literature:

With trichlorophosphate; at 140 ℃; for 4h;

DOI:10.1021/jm301269s

Reference yield:

C6H9NO2 (1314934-13-8) → 2,4-dichloro-6-methyl-pyridine (42779-56-6)

Guidance literature:

With trichlorophosphate; at 120 ℃; for 36h; Inert atmosphere;

DOI:10.1021/jm800743q

Reference yield:

4-hydroxy-6-methyl-2-pyridone (3749-51-7,4664-15-7) → 2,4-dichloro-6-methyl-pyridine (42779-56-6)

Guidance literature:

With trichlorophosphate; at 120 ℃;

upstream raw materials:

4-hydroxy-6-methyl-2-pyridone

2,4-dihydroxy-6-methylpyridine

trichlorophosphate

phosphorus pentachloride

Downstream raw materials:

α-picoline

4,6-dichloro-2-pyridinecarboxylic acid

2,4-dihydroxy-6-methylpyridine

2-chloro-6-methyl-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine

Refernces

• 1、 Dahlgren, Markus K.,Garcia, Alvaro Baeza,Hare, Alissa A.,Tirado-Rives, Julian,Leng, Lin,Bucala, Richard,Jorgensen, William L.. "Virtual screening and optimization yield low-nanomolar inhibitors of the tautomerase activity of Plasmodium falciparum macrophage migration inhibitory factor". supporting information. p. 10148 - 10159. Retrieved 2013/01/16.
• 2、 -. "PYRIDINE DERIVATIVES AND THEIR USE AS MEDICAMENTS FOR TREATING DISEASES RELATED TO MCH RECEPTOR". Page/Page column 71-72. . Retrieved 2010/10/20.