4-AMINO-3-PYRIDINECARBOXAMIDE

Base Information

• Chemical Name: 4-AMINO-3-PYRIDINECARBOXAMIDE
• CAS No.: 7418-66-8
• Molecular Formula: C₆H₇N₃O
• Molecular Weight: 137.141
• Hs Code.: 2933399090
• Mol file: 7418-66-8.mol

Synonyms:Nicotinamide,4-amino- (7CI,8CI);4-Amino-3-pyridinecarboxamide;4-Aminonicotinamide;

Chemical Property of 4-AMINO-3-PYRIDINECARBOXAMIDE

Chemical Property:

• Appearance/Colour: off-white to light yellow crystal powder
• Vapor Pressure: 6.6E-06mmHg at 25°C
• Melting Point: 229.5-230.5 °C
• Refractive Index: 1.643
• Boiling Point: 377.8 °C at 760 mmHg
• PKA: 14.60±0.50(Predicted)
• Flash Point: 182.3 °C
• PSA: 82.00000
• Density: 1.323 g/cm³
• LogP: 1.04420
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Amino-3-pyridinecarboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-AMINO-3-PYRIDINECARBOXAMIDE

There total 6 articles about 4-AMINO-3-PYRIDINECARBOXAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

acetoacetamido (5977-14-0) + 3-methyl-5-nitro-4(3H)-pyrimidinone (17758-33-7) → 4-aminopyridine-3-carboxamide (7418-66-8)

Guidance literature:

With ammonium acetate; In methanol; for 72h; Heating;

DOI:10.1039/b205510d

Reference yield: 27.0%

4-aminonicotinic acid (7418-65-7) → 4-aminopyridine-3-carboxamide (7418-66-8)

Guidance literature:

4-aminonicotinic acid; With thionyl chloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;

With ammonia; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

methyl 4-aminonicotinate (16135-36-7) → 4-aminopyridine-3-carboxamide (7418-66-8)

Guidance literature:

With methanol; ammonia;

DOI:10.1021/jo01138a006

upstream raw materials:

methyl 4-aminonicotinate

4-aminonicotinoyl azide

acetoacetamido

3-methyl-5-nitro-4(3H)-pyrimidinone

Downstream raw materials:

1-{[2-(4-phenoxyphenoxy)ethoxy]methyl}-3-aminocarbonyl-4-aminopyridinium chloride

C₂₀H₂₄N₄O₄

C₂₆H₂₄ClN₅O

C₂₀H₂₂N₄O₃

Refernces

• 1、 Nishiwaki, Nagatoshi,Azuma, Mayumi,Tamura, Mina,Hori, Kazushige,Tohda, Yasuo,Ariga, Masahiro. "Facile synthesis of functionalized 4-aminopyridines". . p. 2170 - 2171. Retrieved 2007/10/03.