Benzaldehyde,4-(4-piperidinyloxy)-

Base Information

• Chemical Name: Benzaldehyde,4-(4-piperidinyloxy)-
• CAS No.: 199103-27-0
• Molecular Formula: C12H15NO2
• Molecular Weight: 205.257
• Mol file: 199103-27-0.mol

Synonyms:4-[(Piperidin-4-yl)oxy]benzaldehyde;4-(4-Piperidyloxy)benzaldehyde;

Chemical Property of Benzaldehyde,4-(4-piperidinyloxy)-

Chemical Property:

• Boiling Point: 358.4 °C at 760 mmHg
• Flash Point: 170.5 °C
• PSA: 38.33000
• Density: 1.117 g/cm³
• LogP: 1.95870

Purity/Quality:

99% ^*data from raw suppliers

4-(PIPERIDIN-4-YLOXY)BENZALDEHYDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzaldehyde,4-(4-piperidinyloxy)-

There total 5 articles about Benzaldehyde,4-(4-piperidinyloxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-HYDROXYPIPERIDINE (5382-16-1) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-(piperidin-4-yloxy)benzaldehyde (199103-27-0)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2007.09.098

Reference yield:

4-(4-formylphenoxy)piperidine-1-carboxylic acid t-butyl ester (207798-38-7) → 4-(piperidin-4-yloxy)benzaldehyde (199103-27-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 25 ℃; for 4h;

DOI:10.1021/jm301164y

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-(piperidin-4-yloxy)benzaldehyde (199103-27-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 100 °C

2: trifluoroacetic acid / dichloromethane / 4 h / 0 - 25 °C

With potassium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm301164y

upstream raw materials:

4-HYDROXYPIPERIDINE

4-hydroxy-benzaldehyde

tert-butyl 4-(tosyloxy)piperidin-1-carboxylate

4-(4-formylphenoxy)piperidine-1-carboxylic acid t-butyl ester

Downstream raw materials:

4-(1-nicotinoylpiperidin-4-yloxy)benzaldehyde

4-(1-picolinoylpiperidin-4-yloxy)benzaldehyde

4-(1-(5-chloropicolinoyl)piperidin-4-yloxy)benzaldehyde

4-(1-(3-(trifluoromethyl)benzoyl)piperidin-4-yloxy)benzaldehyde

Refernces

• 1、 Neff, Danielle K.,Lee-Dutra, Alice,Blevitt, Jonathan M.,Axe, Frank U.,Hack, Michael D.,Buma, Johnathan C.,Rynberg, Raymond,Brunmark, Anders,Karlsson, Lars,Breitenbucher, J. Guy. "2-Aryl benzimidazoles featuring alkyl-linked pendant alcohols and amines as inhibitors of checkpoint kinase Chk2". . p. 6467 - 6471. Retrieved 2008/09/17.