1-methylpiperidine-2-carboxylic Acid Hydrochloride

Base Information

• Chemical Name: 1-methylpiperidine-2-carboxylic Acid Hydrochloride
• CAS No.: 25271-35-6
• Molecular Formula: C7H13 N O2 . Cl H
• Molecular Weight: 179.647
• Hs Code.: 2933399090
• European Community (EC) Number: 675-659-6
• DSSTox Substance ID: DTXSID20948117
• Mol file: 25271-35-6.mol

Synonyms:1-methylpiperidine-2-carboxylic Acid Hydrochloride;25271-35-6;136312-85-1;1-Methyl-piperidine-2-carboxylic acid hydrochloride;1-METHYLPIPERIDINE-2-CARBOXYLIC ACID, HCL;1-Methylpiperidine-2-carboxylic acid HCl;MFCD01570459;1-methylpiperidine-2-carboxylic acid;hydrochloride;1-Methyl-piperidine-2-carboxylic acid;SCHEMBL927104;1-METHYLPIPERIDINE-2-CARBOXYLICACIDHYDROCHLORIDE;DTXSID20948117;HENMKHNMVUDRMJ-UHFFFAOYSA-N;AMY21392;AKOS008105077;AB09264;CS-W021361;SB13698;N-Methyl-DL-pipecolic acid hydrochloride;AS-17957;SY045469;1-methyl-piperidine-2-carboxylic acid hcl;1-methyl-piperidine-2-carboxylic acid x hcl;FT-0638505;EN300-73707;A817752;A848852;N-Methylpiperidine-2-carboxylic acid hydrochloride;J-505006;W-205483;hydron;chloride;(2S)-1-methylpiperidine-2-carboxylic acid;Z1259339901;1-methylpiperidine-2-carboxylic acid hydrochloride, AldrichCPR;1-Methylpiperidine-2-carboxylic acid--hydrogen chloride (1/1)

Chemical Property of 1-methylpiperidine-2-carboxylic Acid Hydrochloride

Chemical Property:

• Vapor Pressure: 0.00899mmHg at 25°C
• Melting Point: 209-212oC
• Boiling Point: 246.1°C at 760 mmHg
• Flash Point: 102.6°C
• PSA: 40.54000
• Density: 1.103g/cm³
• LogP: 1.29520
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 179.0713064
• Heavy Atom Count: 11
• Complexity: 136

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Methylpiperidine-2-carboxylicAcidHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCCCC1C(=O)O.Cl

Technology Process of 1-methylpiperidine-2-carboxylic Acid Hydrochloride

There total 1 articles about 1-methylpiperidine-2-carboxylic Acid Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (R)-(+)-pipecolic acid (1723-00-8,83680-83-5) → (R)-1-methyl-piperidine-2-carboxylic acid ; hydrochloride (25271-35-6,89895-58-9,136312-85-1)

Guidance literature:

With formic acid; for 20h; Heating;

DOI:10.1021/jm050135l

Reference yield: 60.0%

(2S)-1,8-dioxo-1-[(4-phenyl-1,3-thiazol-2-yl)amino]nonan-2-amine trifluoroacetate + 1-methylpiperidine-2-carboxylic acid hydrochloride (25271-35-6) → 1-methyl-N-((1S)-7-oxo-1-([(4-phenyl-1,3-thiazol-2-yl)amino]carbonyl)octyl)piperidine-2-carboxamide

Guidance literature:

1-methylpiperidine-2-carboxylic acid hydrochloride; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;

(2S)-1,8-dioxo-1-[(4-phenyl-1,3-thiazol-2-yl)amino]nonan-2-amine trifluoroacetate; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Further stages.;

DOI:10.1021/jm800079s

Reference yield: 16.0%

2,6-dimethyl-4-fluoroaniline (392-70-1) + 1-methylpiperidine-2-carboxylic acid hydrochloride (25271-35-6) → N-(4-fluoro-2,6-dimethylphenyl)-1-methylpiperidine-2-carboxamide

Guidance literature:

2,6-dimethyl-4-fluoroaniline; With triethylamine; In methanol; dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

With chloroformic acid ethyl ester; In methanol; dichloromethane; at 0 ℃; for 0.333333h; Inert atmosphere;

1-methylpiperidine-2-carboxylic acid hydrochloride; In dichloromethane;

upstream raw materials:

formaldehyd

(R)-(+)-pipecolic acid

Downstream raw materials:

AM₂₂₃₃

(R)-(+)-1-Methyl-2-piperidinemethanol

C₂₂H₂₈N₂O

2-amino-3-(methoxycarbonyl)phenyl 1-methylpiperidine-2-carboxylate

Refernces