PEODA₁₃

Base Information

• Chemical Name: PEODA₁₃
• CAS No.: 361543-12-6
• Molecular Formula: C₂₆H₅₆N₂O₁₂
• Molecular Weight: 588.737
• Mol file: 361543-12-6.mol

Synonyms:PEODA₁₃

Chemical Property of PEODA₁₃

Chemical Property:

Purity/Quality:

99.3% ^*data from raw suppliers

H2N-PEG12-CH2CH2NH2 min.97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of PEODA₁₃

There total 8 articles about PEODA₁₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1,2-bis-{2-[2-(2-{2-[2-(2-azido-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethane (361543-08-0) → PEODA13 (361543-12-6)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; water;

DOI:10.1016/S0040-4039(01)00619-0

Reference yield: 87.0%

C40H66O18S2 → PEODA13 (361543-12-6)

Guidance literature:

With ammonium hydroxide; tetrabutylammomium bromide; In dichloromethane; at 45 ℃; for 12h;

Reference yield:

2-(2-{2-[2-(2-benzyloxyethoxy)ethoxy]ethoxy}ethoxy)ethanol (57671-28-0,1201808-31-2) → PEODA13 (361543-12-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 59 percent / NaH / tetrahydrofuran / Heating

2.1: 77 percent / H₂ / Pd/C 10 percent / methanol / 10343 Torr

3.1: MsCl; Et₃N

3.2: 88 percent / NaN₃ / ethanol

4.1: 89 percent / PPh₃ / tetrahydrofuran; H₂O

With hydrogen; sodium hydride; methanesulfonyl chloride; triethylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; water;

DOI:10.1016/S0040-4039(01)00619-0

upstream raw materials:

1,2-bis-{2-[2-(2-{2-[2-(2-azido-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethane

Pentaethylene glycol

2-(2-{2-[2-(2-benzyloxyethoxy)ethoxy]ethoxy}ethoxy)ethanol

poly(ethylene glycol) 600

Refernces

• 1、 Andrus, Merritt B.,Turner, Timothy M.,Updegraff, Emily P.,Sauna, Zuben E.,Ambudkar, Suresh V.. "Synthesis and analysis of polyethylene glycol linked P-glycoprotein-specific homodimers based on (-)-stipiamide". . p. 3819 - 3822. Retrieved 2007/10/03.