2-BROMO-5-CHLOROANISOLE

Base Information

• Chemical Name: 2-BROMO-5-CHLOROANISOLE
• CAS No.: 174913-09-8
• Molecular Formula: C7H6BrClO
• Molecular Weight: 221.481
• Hs Code.: 29092000
• Mol file: 174913-09-8.mol

Synonyms:1-Bromo-4-chloro-2-methoxybenzene;2-Bromo-5-chlorophenyl methyl ether;benzene, 1-bromo-4-chloro-2-methoxy-;

Chemical Property of 2-BROMO-5-CHLOROANISOLE

Chemical Property:

• Vapor Pressure: 0.0719mmHg at 25°C
• Refractive Index: 1.556
• Boiling Point: 236.645 °C at 760 mmHg
• Flash Point: 96.92 °C
• PSA: 9.23000
• Density: 1.564 g/cm³
• LogP: 3.11110
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99.0% ^*data from raw suppliers

1-Bromo-4-chloro-2-methoxybenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-5-CHLOROANISOLE

There total 3 articles about 2-BROMO-5-CHLOROANISOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-Bromo-5-chlorophenol (13659-23-9) + methyl iodide (74-88-4) → 2-bromo-5-chloroanisole (174913-09-8)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; potassium carbonate; In N,N-dimethyl-formamide; for 2h;

Reference yield: 83.0%

2-methoxy-4-chlorobenzoic acid (57479-70-6) → 2-bromo-5-chloroanisole (174913-09-8)

Guidance literature:

With potassium phosphate; tetrabuthylammonium tribromide; In acetonitrile; at 100 ℃; for 16h;

DOI:10.1039/c8sc01016a

Reference yield:

2-Bromo-5-chlorophenol (13659-23-9) + dimethyl sulfate (77-78-1) → 2-bromo-5-chloroanisole (174913-09-8)

Guidance literature:

With potassium carbonate; In acetone; at 65 ℃; for 18h;

DOI:10.1002/anie.201712718

upstream raw materials:

2-Bromo-5-chlorophenol

methyl iodide

dimethyl sulfate

2-methoxy-4-chlorobenzoic acid

Downstream raw materials:

(5-bromo-2-chloro-6-methoxyphenyl)(4-ethoxyphenyl)methanone

2-Bromo-5-chlorophenol

tert-butyl 4-(4-chloro-2-methoxyphenyl)-3,6-dihydropyridine-1(2H)-carboxylate

(5-bromo-2-chloro-4-methoxyphenyl)(4-ethylphenyl)methanone

Refernces

• 1、 Quibell, Jacob M.,Perry, Gregory J. P.,Cannas, Diego M.,Larrosa, Igor. "Transition-metal-free decarboxylative bromination of aromatic carboxylic acids". . p. 3860 - 3865. Retrieved 2018/04/26.
• 2、 -. "1-THIO-D-GLUCITOL DERIVATIVES". Page/Page column 41-42. . Retrieved 2010/11/28.