N-(2-azidoethyl)-4-octylbenzamide

Base Information

• Chemical Name: N-(2-azidoethyl)-4-octylbenzamide
• CAS No.: 1227623-88-2
• Molecular Formula: C₁₇H₂₆N₄O
• Molecular Weight: 302.42
• Mol file: 1227623-88-2.mol

Synonyms:N-(2-azidoethyl)-4-octylbenzamide

Chemical Property of N-(2-azidoethyl)-4-octylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-azidoethyl)-4-octylbenzamide

There total 2 articles about N-(2-azidoethyl)-4-octylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

1-amino-2-azidoethane (87156-40-9) + p-n-octylbenzoyl chloride (50606-97-8) → N-(2-azidoethyl)-4-octylbenzamide (1227623-88-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1002/cbic.200900617

Reference yield: 69.0%

→ N-(2-azidoethyl)-4-octylbenzamide (1227623-88-2)

Guidance literature:

Reference yield:

2-amino-4-(hept-6-ynyl)-imidazole-1-carboxylic acid tert-butyl ester (1192358-57-8) + N-(2-azidoethyl)-4-octylbenzamide (1227623-88-2) → tert-butyl 2-amino-4-(5-(1-(2-(4-octylbenzamido)ethyl)-1H-1,2,3-triazol-4-yl)pentyl)-1H-imidazole-1-carboxylate (1227623-90-6)

Guidance literature:

With copper(II) sulfate; sodium L-ascorbate; In ethanol; dichloromethane; water; at 20 ℃;

DOI:10.1002/cbic.200900617

upstream raw materials:

1-amino-2-azidoethane

p-n-octylbenzoyl chloride

Downstream raw materials:

tert-butyl 2-amino-4-(5-(1-(2-(4-octylbenzamido)ethyl)-1H-1,2,3-triazol-4-yl)pentyl)-1H-imidazole-1-carboxylate

Refernces

• 1、 Rogers, Steven A.,Bero, Joseph D.,Melander, Christian. "Chemical synthesis and biological screening of 2-aminoimidazole-based bacterial and fungal antibiofilm agents". experimental part. p. 396 - 410. Retrieved 2010/12/19.