2-FLUORO-5-NITROPHENOL

Base Information

• Chemical Name: 2-FLUORO-5-NITROPHENOL
• CAS No.: 22510-08-3
• Molecular Formula: C6H4FNO3
• Molecular Weight: 157.101
• Hs Code.: 2908999090
• Mol file: 22510-08-3.mol

Synonyms:1-Fluoro-2-hydroxy-4-nitrobenzene;

Chemical Property of 2-FLUORO-5-NITROPHENOL

Chemical Property:

• Vapor Pressure: 0.009mmHg at 25°C
• Refractive Index: 1.582
• Boiling Point: 256.726 °C at 760 mmHg
• PKA: 6.95±0.19(Predicted)
• Flash Point: 109.065 °C
• PSA: 66.05000
• Density: 1.512 g/cm³
• LogP: 1.96270
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Fluoro-5-nitrophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Fluoro-5-nitrophenol

Technology Process of 2-FLUORO-5-NITROPHENOL

There total 4 articles about 2-FLUORO-5-NITROPHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-fluoro-3-nitroaniline (369-36-8) → 2-fluoro-5-nitrophenol (22510-08-3)

Guidance literature:

With sodium nitrite; In sulfuric acid; water;

Reference yield:

2-methoxy-4-nitrobenzenediazonium tetrafluoroborate → 2-fluoro-5-nitrophenol (22510-08-3)

Guidance literature:

With silica gel;

Reference yield:

isopropyl alcohol (67-63-0,8013-70-5) + 3-(2-fluoro-4-nitrophenoxymethyl)-5-methoxy-1,2-dimethylindole-4,7-dione → 3-(hydroxymethyl)-5-methoxy-1,2-dimethyl-1H-indole-4,7-dione (161518-24-7) + 3-(isopropoxy)methyl-5-methoxy-1,2-dimethylindole-4,7-dione + 2-fluoro-5-nitrophenol (22510-08-3)

Guidance literature:

With dinitrogen monoxide; In water; Kinetics; γ-Irradiation;

DOI:10.1039/b101842f

upstream raw materials:

isopropyl alcohol

6-fluoro-3-nitroaniline

Downstream raw materials:

2-(difluoromethoxy)-1-fluoro-4-nitrobenzene

2-(4-methylpiperazine)-5-nitrophenol

2-(2-hydroxy-4-nitrophenyl)isoindoline-1,3-dione

Refernces

• 1、 Swann,Moody,Stratford,Patel,Naylor,Vojnovic,Wardman,Everett. "Rates of reductive elimination of substituted nitrophenols from the (indol-3-yl)methyl position of indolequinones". . p. 1340 - 1345. Retrieved 2007/10/03.
• 2、 -. "Phenyl benzoic acid compounds". . . Retrieved 2008/06/13.