DIMETHY-4-FLUOROPHTHALATE

Base Information

• Chemical Name: DIMETHY-4-FLUOROPHTHALATE
• CAS No.: 110706-50-8
• Molecular Formula: C10H9FO4
• Molecular Weight: 212.17
• Hs Code.: 2917399090
• Mol file: 110706-50-8.mol

Synonyms:1,2-Benzenedicarboxylicacid, 4-fluoro-, dimethyl ester (9CI);Dimethyl 4-fluorophthalate;

Chemical Property of DIMETHY-4-FLUOROPHTHALATE

Chemical Property:

• Appearance/Colour: slight yellow liquid
• Boiling Point: 251.994 °C at 760 mmHg
• Flash Point: 103.127 °C
• PSA: 52.60000
• Density: 1.252 g/cm³
• LogP: 1.39890
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

1,2-BENZENEDICARBOXYLIC ACID,4-FLUORO-,1,2-DIMETHYL ESTER 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DIMETHY-4-FLUOROPHTHALATE

There total 7 articles about DIMETHY-4-FLUOROPHTHALATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methanol (67-56-1) + 4-fluorophthalic anhydride (319-03-9) → dimethyl 4-fluorophthalate (110706-50-8)

Guidance literature:

With thionyl chloride; at 65 ℃; for 6h;

DOI:10.1021/acs.jmedchem.9b01585

Reference yield:

4-fluorophthalic anhydride (319-03-9) → dimethyl 4-fluorophthalate (110706-50-8)

Guidance literature:

With thionyl chloride; In methanol; (2S)-N-methyl-1-phenylpropan-2-amine hydrate;

Reference yield:

4-chloro-cyclohexa-1,4-diene-1,2-dicarboxylic acid dimethyl ester (99070-89-0) → dimethyl 4-fluorophthalate (110706-50-8)

Guidance literature:

With N-Bromosuccinimide; potassium carbonate; pyridine hydrogenfluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In water;

upstream raw materials:

2-fluoro-1-trimethylsilyloxy-1,3-butadiene

dimethyl acetylenedicarboxylate

4-fluorophthalic anhydride

4-chloro-cyclohexa-1,4-diene-1,2-dicarboxylic acid dimethyl ester

Downstream raw materials:

dimethyl 4-(1H-1-pyrazolyl)phthalate

4-fluoro-2-(hydroxymethyl)benzyl alcohol

2,2'-(4-fluoro-1,2-phenylene)bis(2-propanol)

Refernces

• 1、 Hayashi, Tsuyoshi,Usuki, Yoshinosuke,Wakamatsu, Yosuke,Iio, Hideo. "Synthesis of (E)-1-benzyloxy-3-fluoro-1,3-butadiene: A novel fluorinated diene for Diels-Alder reactions". supporting information; body text. p. 2843 - 2846. Retrieved 2011/02/16.
• 2、 -. "Phthalazine derivatives and remedies for erectile dysfunction". . . Retrieved 2008/06/13.