Technology Process of -(+)-1-chloro-3-phenyl-3-(2-methoxyphenoxy)propane
There total 6 articles about -(+)-1-chloro-3-phenyl-3-(2-methoxyphenoxy)propane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triphenylphosphine; diethylazodicarboxylate;
In
diethyl ether;
at -10 ℃;
for 5h;
DOI:10.1016/j.bmc.2005.04.062
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 88 percent / NaBH4 / ethanol / 2 h / 20 °C
2: 93 percent / pyridine; DMAP / CH2Cl2 / 0 - 20 °C
3: aq. phosphate buffer; Novozyme 435 / 288 h / 30 °C / pH 7
4: 42 percent / PPh3; diethyl azodicarboxylate / tetrahydrofuran / 20 °C
With
pyridine; dmap; sodium tetrahydroborate; phosphate buffer; novozyme 435; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; ethanol; dichloromethane;
1: Reduction / 2: Esterification / 3: Hydrolysis / 4: Etherification;
DOI:10.1039/b000846j
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 93 percent / pyridine; DMAP / CH2Cl2 / 0 - 20 °C
2: aq. phosphate buffer; Novozyme 435 / 288 h / 30 °C / pH 7
3: 42 percent / PPh3; diethyl azodicarboxylate / tetrahydrofuran / 20 °C
With
pyridine; dmap; phosphate buffer; novozyme 435; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; dichloromethane;
1: Esterification / 2: Hydrolysis / 3: Etherification;
DOI:10.1039/b000846j