2-Fluoro-6-formylpyridine

Base Information

• Chemical Name: 2-Fluoro-6-formylpyridine
• CAS No.: 208110-81-0
• Molecular Formula: C6H4FNO
• Molecular Weight: 125.102
• Hs Code.: 2933399090
• European Community (EC) Number: 675-079-3
• DSSTox Substance ID: DTXSID70442317
• Wikidata: Q72479847
• Mol file: 208110-81-0.mol

Synonyms:208110-81-0;2-Fluoro-6-formylpyridine;6-fluoropicolinaldehyde;6-fluoropyridine-2-carbaldehyde;6-Fluoropyridine-2-carboxaldehyde;6-Fluoro-pyridine-2-carbaldehyde;6-fluoro-2-pyridinecarboxaldehyde;2-Pyridinecarboxaldehyde, 6-fluoro-;2-fluoropyridine-6-carboxaldehyde;MFCD03095149;6-Fluoro-2-pyridinecarbaldehyde;SCHEMBL361283;DTXSID70442317;HENWRHPVXMPQNF-UHFFFAOYSA-N;Pyridine2-fluoro-6-carboxaldehyde;6-fluoro-2-pyridinecarboxyaldehyde;BCP33720;BBL103796;STL557606;AKOS006220673;AB13533;AC-5945;CS-W003025;PS-9204;SY014043;AM20061673;FT-0649122;EN300-130330;A814931;W-206560;6-Fluoropicolinaldehyde

Chemical Property of 2-Fluoro-6-formylpyridine

Chemical Property:

• Vapor Pressure: 0.0028mmHg at 25°C
• Refractive Index: 1.513
• Boiling Point: 192.378 °C at 760 mmHg
• PKA: 0.80±0.10(Predicted)
• Flash Point: 70.148 °C
• PSA: 29.96000
• Density: 1.27 g/cm³
• LogP: 1.03320
• Storage Temp.: Store Cold
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 125.027691913
• Heavy Atom Count: 9
• Complexity: 107

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Fluoro-6-formylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi, F
• Hazard Codes: Xi,F
• Statements: 10-36/37/38
• Safety Statements: 16-26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC(=C1)F)C=O
• Uses: 2-Fluoro-6-formylpyridine is used in the synthesis of fluoroheterocyclic aldoximes which are therapeutic agents for the treatment of anti-cholinesterase poisoning.

Technology Process of 2-Fluoro-6-formylpyridine

There total 8 articles about 2-Fluoro-6-formylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

methyl 6-fluoropyridine-2-carboxylate (455-71-0) → 2-Fluoropyridine-6-carboxaldehyde (208110-81-0)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; at -55 ℃; for 3h; Inert atmosphere;

DOI:10.1021/acs.organomet.9b00469

Reference yield: 68.0%

6-fluoropyridine-2-carbonyl chloride (64197-03-1) → 2-Fluoropyridine-6-carboxaldehyde (208110-81-0)

Guidance literature:

With Pd-BaSO₄; hydrogen;

DOI:10.1016/j.jfluchem.2011.05.028

Reference yield: 60.0%

2-fluoro-6-(dibromomethyl)pyridine (1243694-61-2) → 2-Fluoropyridine-6-carboxaldehyde (208110-81-0)

Guidance literature:

With silver nitrate; In water; acetonitrile; at 20 ℃; for 3h;

DOI:10.1021/ic1006567

upstream raw materials:

2-fluoro-6-methylpyridine

tert-Butoxybis(dimethylamino)methane

2-fluoro-6-(dibromomethyl)pyridine

6-fluoropyridine-2-carbonyl chloride

Downstream raw materials:

benzhydrylidene-{5-[2-(6-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-6-propyl-pyrazin-2-yl}-amine

Refernces

• 1、 Byun, Seunghwan,Seo, Huiyeong,Choi, Jun-Ho,Ryu, Ji Yeon,Lee, Junseong,Chung, Won-Jin,Hong, Sukwon. "Fluoro-imidazopyridinylidene Ruthenium Catalysts for Cross Metathesis with Ethylene". . p. 4121 - 4132. Retrieved 2019/10/16.
• 2、 -. "SUSTITUTED IMIDAZOLOPYRAZINE AND TRIAZOLOPYRAZINE DERIVATIVES: GABAA RECEPTOR LIGANDS". Page 37. . Retrieved 2008/06/13.