4-(4-Methylphenyl)piperidine

Base Information

• Chemical Name: 4-(4-Methylphenyl)piperidine
• CAS No.: 59083-39-5
• Molecular Formula: C12H17N
• Molecular Weight: 175.274
• Hs Code.: 2933399090
• Mol file: 59083-39-5.mol

Synonyms:4-(4-Methylphenyl)piperidine;4-(p-Tolyl)piperidine;

Chemical Property of 4-(4-Methylphenyl)piperidine

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.515
• Boiling Point: 281.5 °C at 760 mmHg
• Flash Point: 126.8 °C
• PSA: 12.03000
• Density: 0.958 g/cm³
• LogP: 2.79080
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%Min ^*data from raw suppliers

4-(4-Methylphenyl)piperidine ^*data from reagent suppliers

Safty Information:

• Statements: 52

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-Methylphenyl)piperidine

There total 11 articles about 4-(4-Methylphenyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-p-tolyl-piperidine-2,6-dione → 1,2,5,6-tetrahydro-4-(4-methylphenyl)-piperidine (59083-39-5)

Guidance literature:

With borane-THF; In tetrahydrofuran; for 19h; Heating;

DOI:10.1016/j.bmc.2005.11.044

Reference yield:

3-p-tolyl-pentanedioic acid dimethyl ester → 1,2,5,6-tetrahydro-4-(4-methylphenyl)-piperidine (59083-39-5)

Guidance literature:

Multi-step reaction with 2 steps

1: urea; NaOEt / ethanol / 17 h / Heating

2: borane-tetrahydrofuran / tetrahydrofuran / 19 h / Heating

With borane-THF; sodium ethanolate; urea; In tetrahydrofuran; ethanol;

DOI:10.1016/j.bmc.2005.11.044

Reference yield:

2-cyano-4-ethoxycarbonyl-3-p-tolyl-pentanedioic acid diethyl ester → 1,2,5,6-tetrahydro-4-(4-methylphenyl)-piperidine (59083-39-5)

Guidance literature:

Multi-step reaction with 4 steps

1: aq. HCl / 60 h / Heating

2: thionyl chloride / 17.5 h

3: urea; NaOEt / ethanol / 17 h / Heating

4: borane-tetrahydrofuran / tetrahydrofuran / 19 h / Heating

With hydrogenchloride; thionyl chloride; borane-THF; sodium ethanolate; urea; In tetrahydrofuran; ethanol;

DOI:10.1016/j.bmc.2005.11.044

upstream raw materials:

1,2,3,6-tetrahydropyridine

toluene

2-(4-methylphenyl)-1,3-dioxolane

p-bromobenzaldehyde 1,3-dioxolane

Downstream raw materials:

2-(4-para-tolylpiperidin-1-yl)benzo[d]oxazole

6-(2-(4-p-tolylpiperidin-1-yl)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one

(3-amino-4-methyl-phenyl)-[4-(4-methylphenyl)-1-piperidyl]methanone

(2S)-(-)-1-(4-indolyloxy)-3-(4-(4-methylphenyl)piperidin-1-yl)-2-propanol ethanedioate

Refernces

• 1、 -. "AZABENZIMIDAZOLYL COMPOUNDS". Page/Page column 65. . Retrieved 2008/06/13.
• 2、 Shiba, Kazuhiro,Ogawa, Kazuma,Ishiwata, Kiichi,Yajima, Kazuyoshi,Mori, Hirofumi. "Synthesis and binding affinities of methylvesamicol analogs for the acetylcholine transporter and sigma receptor". . p. 2620 - 2626. Retrieved 2007/10/03.