3-IODOISONICOTINIC ACID

Base Information

• Chemical Name: 3-IODOISONICOTINIC ACID
• CAS No.: 57842-10-1
• Molecular Formula: C6H4INO2
• Molecular Weight: 249.008
• Hs Code.: 29333990
• Mol file: 57842-10-1.mol

Synonyms:Isonicotinicacid, 3-iodo- (6CI);3-Iodo-4-pyridinecarboxylic acid;

Chemical Property of 3-IODOISONICOTINIC ACID

Chemical Property:

• Vapor Pressure: 2.31E-08mmHg at 25°C
• Melting Point: 205-210 °C
• Refractive Index: 1.677
• Boiling Point: 435.7 °C at 760 mmHg
• Flash Point: 217.3 °C
• PSA: 50.19000
• Density: 2.123 g/cm³
• LogP: 1.38440
• Storage Temp.: Keep Cold

Purity/Quality:

98%min ^*data from raw suppliers

3-IodoisonicotinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Iodoisonicotinic Acid, is an Antituberculotics. It is used on its own for the control of latent tuberculosis and in combination with other drugs for active TB. It works by inhibiting the formation of mycolic acid in the cell wall of Mycobacterium tuberculosis.

Technology Process of 3-IODOISONICOTINIC ACID

There total 11 articles about 3-IODOISONICOTINIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

lithium; 3-iodo-isonicotinate → 3-iodo-4-pyridinecarboxylic acid (57842-10-1)

Guidance literature:

With Amberlyst(R) IR-200; In methanol; at 20 ℃; for 0.25h;

DOI:10.1016/S0040-4020(02)00673-7

Reference yield:

cinchomeronic anhydride (4664-08-8) → 3-iodo-4-pyridinecarboxylic acid (57842-10-1)

Guidance literature:

Multi-step reaction with 3 steps

1: MeCONH₂ / Heating

2: 69 percent / Br₂ / aq. NaOH / 80 °C

3: 1.) H⁽¹⁺⁾, NaNO₂; 2.) KI / 1.) O deg C; 2.) 50-60 deg C

With acetamide; bromine; hydrogen cation; potassium iodide; sodium nitrite; In sodium hydroxide;

DOI:10.1016/S0040-4039(00)73716-6

Reference yield:

methyl 3-iodo-4-pyridinecarboxylate (188677-49-8) → 3-iodo-4-pyridinecarboxylic acid (57842-10-1)

Guidance literature:

methyl 3-iodo-4-pyridinecarboxylate; With water; sodium hydroxide; at 60 ℃; for 3h;

With hydrogenchloride; In water; pH=2 - 3; Cooling with ice;

upstream raw materials:

3-iodo-4-methyl-pyridine

3-Aminopyridine-4-carboxylic acid

3-iodo-isonicotinanilide

pyridine-4-carboxylic acid

Downstream raw materials:

methyl 3-iodo-4-pyridinecarboxylate

N-[2-hydroxy-5-(trifluoromethyl)phenyl]-3-iodoisonicotinamide

2-(3-phenyl pyridin-4-yl)-5-(trifluoromethyl)benzoxazole

2-(3-ethylpyridin-4-yl)-5-(trifluoromethyl)benzoxazole

Refernces

• 1、 -. "HARMFUL ARTHROPOD CONTROL COMPOSITION, AND FUSED HETEROCYCLIC COMPOUND". Page/Page column 80. . Retrieved 2011/04/13.
• 2、 -. "COMPOSITION AND METHOD FOR CONTROLLING ARTHROPOD PESTS". Page/Page column 210. . Retrieved 2011/05/06.