2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride

Base Information

• Chemical Name: 2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride
• CAS No.: 289686-69-7
• Molecular Formula: C₁₂H₉ClF₆O
• Molecular Weight: 318.646
• Mol file: 289686-69-7.mol

Synonyms:2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride

Chemical Property of 2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride

Chemical Property:

Purity/Quality:

98.00% ^*data from raw suppliers

2-(3,5-BIS-(TRIFLUOROMETHYL)PHENYL)-2-METHYLPROPANOYL CHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride

There total 5 articles about 2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0) → 2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride (289686-69-7)

Guidance literature:

With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; toluene; for 4.5h;

Reference yield: 100.0%

oxalyl dichloride (79-37-8) + α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0) → 2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride (289686-69-7)

Guidance literature:

In dichloromethane; N,N-dimethyl-formamide; for 4.5h;

Reference yield:

3,6-bis(trifluoromethyl)bromobenzene (328-70-1) → 2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride (289686-69-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: magnesium / diethyl ether / 1 h / 30 °C

1.2: diethyl ether / 0.75 h / 16 - 22 °C

2.1: 97 percent / CF₃SO₃H / CH₂Cl₂; H₂O / 2 h / 20 °C / 22501.8 Torr

3.1: (COCl)2 / CH₂Cl₂; dimethylformamide / 17 h / 0 - 20 °C

With oxalyl dichloride; trifluorormethanesulfonic acid; magnesium; In diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jo0523666

upstream raw materials:

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

3,6-bis(trifluoromethyl)bromobenzene

α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanol

oxalyl dichloride

Downstream raw materials:

α,α-dimethyl-N-[4-oxo-1-phenylcyclohexyl]-3,5-bis(trifluoromethyl)benzeneacetamide

2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-N-[4-(4-fluoro-2-methyl-phenyl)-6-thiomorpholin-4-yl-pyridin-3-yl]-isobutyramide

2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-chloro-4-(2-chloro-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide

C₂₂H₂₁F₆NO₃

Refernces

• 1、 -. "4-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-((phosphonooxy)methyl)piperazin-1-ium as a neurokinin receptor modulator". Page/Page column 31; 32. . Retrieved 2016/08/29.
• 2、 -. "SUBSTITUTED 4-PHENYL-PYRIDINES FOR TREATMENT OF NK-1 RECEPTOR RELATED DISEASES". Paragraph 0157-0159. . Retrieved 2018/10/31.