3-Bromo-2-hydroxy-5-nitropyridine

Base Information

• Chemical Name: 3-Bromo-2-hydroxy-5-nitropyridine
• CAS No.: 15862-33-6
• Molecular Formula: C5H3BrN2O3
• Molecular Weight: 218.994
• Hs Code.: 2933399090
• European Community (EC) Number: 640-197-6
• DSSTox Substance ID: DTXSID40346570
• Wikidata: Q72456964
• ChEMBL ID: CHEMBL1478899
• Mol file: 15862-33-6.mol

Synonyms:3-Bromo-2-hydroxy-5-nitropyridine;15862-33-6;3-bromo-5-nitropyridin-2-ol;3-Bromo-5-nitro-1H-pyridin-2-one;2-HYDROXY-3-BROMO-5-NITROPYRIDINE;3-Bromo-5-nitro-2-pyridinol;2(1H)-Pyridinone, 3-bromo-5-nitro-;MFCD03840431;3-Bromo-5-nitro-2-hydroxypyridine;MLS000553680;3-Bromo-5-nitro-2-pyridone;SCHEMBL2405141;CHEMBL1478899;DTXSID40346570;3-Bromo-5-nitro-2-pyridinol #;HMS2521L22;Pyridin-2-ol, 3-bromo-5-nitro-;CS-D0770;STK682362;AKOS000538773;AKOS001729498;AC-8290;DS-0620;PS-3646;SMR000171625;SY022511;3-Bromo-2-hydroxy-5-nitropyridine, 95%;3-bromo-5-nitro-1,2-dihydropyridin-2-one;A3498;AM20070231;B4672;FT-0648854;EN300-105400;W-205822

Chemical Property of 3-Bromo-2-hydroxy-5-nitropyridine

Chemical Property:

• Vapor Pressure: 0.00109mmHg at 25°C
• Melting Point: 213-218℃
• Refractive Index: 1.647
• Boiling Point: 300.9 °C at 760 mmHg
• PKA: 6.58±0.10(Predicted)
• Flash Point: 135.8 °C
• PSA: 78.94000
• Density: 1.98 g/cm³
• LogP: 1.98110
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 217.93270
• Heavy Atom Count: 11
• Complexity: 276

Purity/Quality:

99% ^*data from raw suppliers

3-Bromo-5-nitro-2(1H)-pyridinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=O)NC=C1[N+](=O)[O-])Br

Technology Process of 3-Bromo-2-hydroxy-5-nitropyridine

There total 4 articles about 3-Bromo-2-hydroxy-5-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-nitro-2-hydroxypyridine (5418-51-9) → 3-bromo-2-hydroxy-5-nitropyridine (15862-33-6)

Guidance literature:

With bromine; In water; at 5 ℃; for 2.5h;

Reference yield: 74.0%

3-bromo-2-fluoro-5-nitropyridine (1868-58-2) → 3-bromo-2-hydroxy-5-nitropyridine (15862-33-6)

Guidance literature:

With 18-crown-6 ether; potassium hydroxide; In neat (no solvent); for 1h; Milling; Sealed tube; Green chemistry;

DOI:10.1039/d1gc04361g

Reference yield:

→ 3-bromo-2-hydroxy-5-nitropyridine (15862-33-6)

Guidance literature:

With sulfuric acid; water;

DOI:10.1021/ja01520a021

upstream raw materials:

5-nitro-2-hydroxypyridine

3-bromo-2-fluoro-5-nitropyridine

Downstream raw materials:

3-bromo-2-chloro-5-nitropyridine

2,3-dibromo-5-nitropyridine

3-bromo-2-methoxy-5-nitropyridine

methyl[3(S),5(R),6(S),7(S)]-6-(4-fluorophenyl)-3-[2-isopropoxy-5-(5-trifluoromethyl-tetrazol-1-yl)-pyridin-3-yl]-1-oxa-spiro[4.4]nonane-7-carboxylate

Refernces

• 1、 -. "Compounds for inflammation and immune-related uses". Page/Page column 253-254. . Retrieved 2017/05/10.
• 2、 -. "A 2-amino-thiazole compounds (by machine translation)". Paragraph 0716-0718. . Retrieved 2016/10/08.