2,3-Dichloropyridine-4-carboxaldehyde

Base Information

• Chemical Name: 2,3-Dichloropyridine-4-carboxaldehyde
• CAS No.: 884495-41-4
• Molecular Formula: C6H3Cl2NO
• Molecular Weight: 176.002
• Hs Code.: 2933399090
• Mol file: 884495-41-4.mol

Synonyms:2,3-dichloropyridine-4-carbaldehyde

Chemical Property of 2,3-Dichloropyridine-4-carboxaldehyde

Chemical Property:

• Vapor Pressure: 0.061mmHg at 25°C
• Melting Point: 94-96 °C
• Refractive Index: 1.537
• Boiling Point: 262.2 °C at 760 mmHg
• PKA: -2.00±0.10(Predicted)
• Flash Point: 112.4 °C
• PSA: 29.96000
• Density: 1.488 g/cm³
• LogP: 2.20090
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2,3-Dichloroisonicotinaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,3-Dichloroisonicotinaldehyde is used in preparation of spiroaminoindene piperidines as Shp2 phosphatase inhibitors for treatment of disorders associated with SHP2 deregulation.

Technology Process of 2,3-Dichloropyridine-4-carboxaldehyde

There total 1 articles about 2,3-Dichloropyridine-4-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.9%

2,3-dichloro-pyridine (2402-77-9) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2,3-dichloropyridine-4-carbaldehyde (884495-41-4)

Guidance literature:

2,3-dichloro-pyridine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h;

With water; In tetrahydrofuran; hexane; at 20 ℃;

Reference yield: 79.0%

2,3-dichloropyridine-4-carbaldehyde (884495-41-4) + methyl 3-amino-5-chloro-4-hydroxybenzoate (40258-68-2) → 7-chloro-2-(2,3-dichloropyridin-4-yl)benzo[d]oxazole-5-carboxylic acid methyl ester

Guidance literature:

2,3-dichloropyridine-4-carbaldehyde; methyl 3-amino-5-chloro-4-hydroxybenzoate; In tetrahydrofuran; at 20 - 25 ℃; for 1h; Inert atmosphere;

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 20 - 25 ℃; for 1h; Inert atmosphere;

Reference yield: 67.0%

2,3-dichloropyridine-4-carbaldehyde (884495-41-4) + 1-(2-pyrimidyl)piperazine dihydrochloride (94021-22-4) → 2-[4-(2,3-dichloropyridin-4-ylmethyl)piperazin-1-yl]pyrimidine (1152617-79-2)

Guidance literature:

With sodium triacetoxyborohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 24h;

upstream raw materials:

2,3-dichloro-pyridine

N,N-dimethyl-formamide

Downstream raw materials:

2-[4-(2,3-dichloropyridin-4-ylmethyl)piperazin-1-yl]pyrimidine

2,3-dichloro-4-(3H-spiro[2-benzofuran-1,4'-piperidine]-1'-yl)methylpyridine

2,3-dichloro-4-[(4-phenyl-piperidin-1-yl)methyl]pyridine

2,3-dichloro-4-(difluoromethyl)pyridine

Refernces

• 1、 -. "N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS". Page/Page column 57. . Retrieved 2010/12/29.