4-Fluoro-3-methylpyridine

Base Information

• Chemical Name: 4-Fluoro-3-methylpyridine
• CAS No.: 28489-28-3
• Molecular Formula: C₆H₆FN
• Molecular Weight: 111.119
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID00376575
• Wikidata: Q72474898
• Mol file: 28489-28-3.mol

Synonyms:4-Fluoro-3-methylpyridine;28489-28-3;4-Fluoro-3-picoline;4-fluoro-3-methyl-pyridine;Pyridine, 4-fluoro-3-methyl-;SCHEMBL2425486;AMY6492;DTXSID00376575;UHNUYEACFGAWEG-UHFFFAOYSA-N;MFCD04114241;AKOS006293181;AB18013;CS-W022179;DS-18400;FT-0650320;F19730;A819473;J-515384

Chemical Property of 4-Fluoro-3-methylpyridine

Chemical Property:

• Vapor Pressure: 6.13mmHg at 25°C
• Refractive Index: 1.477
• Boiling Point: 145.4 °C at 760 mmHg
• PKA: 4.40±0.18(Predicted)
• Flash Point: 41.8 °C
• PSA: 12.89000
• Density: 1.077 g/cm³
• LogP: 1.52910
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 111.048427358
• Heavy Atom Count: 8
• Complexity: 74.9

Purity/Quality:

99% ^*data from raw suppliers

4-Fluoro-3-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CN=C1)F

Technology Process of 4-Fluoro-3-methylpyridine

There total 1 articles about 4-Fluoro-3-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 4-fluoro-3-methyl-pyridine (28489-28-3)

Guidance literature:

aus 4-Amino-3-methyl-pyridin;

DOI:10.1139/v72-372

Reference yield: 99.0%

4-fluoro-3-methyl-pyridine (28489-28-3) → C6H12FN*ClH

Guidance literature:

4-fluoro-3-methyl-pyridine; With C₃₁H₄₈ClNRh; hydrogen; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In tetrahydrofuran; at 40 ℃; for 24h; under 37503.8 Torr; Molecular sieve; Autoclave;

With trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane; at 20 ℃; for 0.166667h;

With hydrogenchloride; In tetrahydrofuran; dichloromethane; diastereoselective reaction;

DOI:10.1038/s41557-018-0197-2

Reference yield: 41.0%

4-fluoro-3-methyl-pyridine (28489-28-3) + tributyltin chloride (1461-22-9) → 4-fluoro-3-methyl-5-(tributylstannyl)pyridine (1220696-54-7)

Guidance literature:

4-fluoro-3-methyl-pyridine; With lithium diisopropyl amide; In tetrahydrofuran; methanol; n-heptane; dichloromethane; ethylbenzene; at -78 ℃; for 0.6h; Inert atmosphere;

tributyltin chloride; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 - 25 ℃; for 2.03333h;

Downstream raw materials:

4-fluoro-3-methyl-5-(tributylstannyl)pyridine

(R)-5-(3-amino-4-fluoro-1-(3-(4-fluoro-5-methylpyridin-3-yl)phenyl)-1H-isoindol-1-yl)-1-ethyl-3-methylpyridin-2(1H)-one