(4-Bromophenoxy)(tert-butyl)dimethylsilane

Base Information

• Chemical Name: (4-Bromophenoxy)(tert-butyl)dimethylsilane
• CAS No.: 67963-68-2
• Molecular Formula: C12H19BrOSi
• Molecular Weight: 287.272
• Hs Code.: 29319090
• European Community (EC) Number: 628-250-1
• DSSTox Substance ID: DTXSID70401025
• Nikkaji Number: J643.230A
• Wikidata: Q72449105
• Mol file: 67963-68-2.mol

Synonyms:67963-68-2;(4-Bromophenoxy)(tert-butyl)dimethylsilane;(4-Bromophenoxy)-tert-butyldimethylsilane;1-Bromo-4-(tert-butyldimethylsiloxy)benzene;(4-bromophenoxy)-tert-butyl-dimethylsilane;4-Bromophenol tert-Butyldimethylsilyl Ether;p-bromophenoxy(t-butyl)dimethylsilane;Silane, (4-bromophenoxy)(1,1-dimethylethyl)dimethyl-;4-bromophenoxy(tert-butyl)dimethylsilane;SCHEMBL614621;4-Bromophenol, TBDMS derivative;DTXSID70401025;4-bromo t-butyldimethylsiloxybenzene;p-bromo-t-butyldimethylsiloxybenzene;MFCD00239382;4-bromo-t-butyldimethylsilyloxybenzene;4-Bromophenoxy t-Butyl-Dimethylsilane;p-bromo-t-butyldimethylsilyloxybenzene;Thiomorpholine, 3-(2-chlorophenyl)-;(4-bromophenoxy)-t-butyldimethylsilane;AKOS000277748;4-tert-butyldimethylsilyloxybromobenzene;AM87135;CS-W012214;4-(t-butyldimethylsilyloxy)-bromobenzene;1-bromo-4-(t-butyldimethylsiloxy)benzene;1-bromo-4-t-butyldimethylsilyloxy-benzene;4-bromo-1-(t-butyldimethylsiloxy)benzene;4-bromo-phenoxy-tert-butyldimethyl silane;CS-17355;(4-bromo-phenoxy)-tert-butyl-dimethylsilane;4-Bromophenol, tert-butyldimethylsilyl ether;B6264;FT-0663832;(4-Bromo-phenoxy)-tert-butyl-dimethyl-silane;(4-bromophenoxy)-(tert-butyl)dimethyl-silane;(4-Bromophenoxy)-tert-butyldimethylsilane, 97%;EN300-1272769;A867154;InChI=1/C12H19BrOSi/c1-12(2,3)15(4,5)14-11-8-6-10(13)7-9-11/h6-9H,1-5H

Chemical Property of (4-Bromophenoxy)(tert-butyl)dimethylsilane

Chemical Property:

• Vapor Pressure: 0.0163mmHg at 25°C
• Refractive Index: n20/D 1.511(lit.)
• Boiling Point: 264 °C at 760 mmHg
• Flash Point: 113.5 °C
• PSA: 9.23000
• Density: 1.158 g/cm³
• LogP: 4.83310
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 286.03885
• Heavy Atom Count: 15
• Complexity: 202

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Bromophenoltert-ButyldimethylsilylEther ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,Xi
• Hazard Codes: F,Xi
• Statements: 11-36/37/38
• Safety Statements: 16-26-36-37/39-60-37-23

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)[Si](C)(C)OC1=CC=C(C=C1)Br

Technology Process of (4-Bromophenoxy)(tert-butyl)dimethylsilane

There total 12 articles about (4-Bromophenoxy)(tert-butyl)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-bromo-phenol (106-41-2) + tert-butyldimethylsilyl chloride (18162-48-6) → t-butyldimethylsilyl-4-bromophenol (67963-68-2)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 35 ℃; for 0.5h;

Reference yield: 98.0%

4-bromo-phenol (106-41-2) + C7H16O2Si (111864-19-8) → t-butyldimethylsilyl-4-bromophenol (67963-68-2)

Guidance literature:

With [Ru(κ¹-OAc)(κ²-OAc)(κ³-1,1,1-tris(diphenylphosphinomethyl)ethane)]; In acetonitrile; at 70 ℃; for 1h; Inert atmosphere; Schlenk technique; Sealed tube;

Reference yield: 98.0%

4-bromo-phenol (106-41-2) + t-butyldimethylsilyl trichloroacetate (108613-05-4) → t-butyldimethylsilyl-4-bromophenol (67963-68-2)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; at 150 ℃; for 3h;

DOI:10.1016/S0040-4039(00)85116-3

upstream raw materials:

4-bromo-phenol

t-butyldimethylsilyl trichloroacetate

tert-butyldimethylsilyl chloride

4-bromophenyl acetate

Downstream raw materials:

1-[(tert-butyldimethylsilyl)oxy]-4-ethynylbenzene

4-bromo-phenol

p-benzyloxyphenylbromide

4-bromophenyl acetate

Refernces

• 1、 Huang, Chiao-Ling,Kung, Yu-Ruei,Liou, Guey-Sheng,Shao, Yu-Jen. "Synthesis and characteristics of novel TPA-containing electrochromic poly(ether sulfone)s with dimethylamino substituents". . . Retrieved 2021.
• 2、 Mandai, Hiroki,Hironaka, Tsubasa,Mitsudo, Koichi,Suga, Seiji. "Acylative desymmetrization of cyclic meso-1,3-diols by chiral DMAP derivatives". supporting information. p. 471 - 474. Retrieved 2021/03/15.