1-(1-phenylcyclohexyl)ethan-1-ol

Base Information

• Chemical Name: 1-(1-phenylcyclohexyl)ethan-1-ol
• CAS No.: 1344924-39-5
• Molecular Formula: C₁₄H₂₀O
• Molecular Weight: 204.312
• Mol file: 1344924-39-5.mol

Synonyms:1-(1-phenylcyclohexyl)ethan-1-ol

Chemical Property of 1-(1-phenylcyclohexyl)ethan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 1-(1-phenylcyclohexyl)ethan-1-ol

There total 4 articles about 1-(1-phenylcyclohexyl)ethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3,5-dimethylphenyl)dimethyl(1-(1-phenylcyclohexyl)ethoxy)silane → 1-(1-phenylcyclohexyl)ethan-1-ol (1344924-39-5) + 1-(1-phenylcyclohexyl)ethan-1-ol (1344956-92-8)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.0c03943

Reference yield:

rac-1-(1-phenylcyclohexyl)ethan-1-ol (6555-65-3) + (3,5-dimethylphenyl)dimethylsilane → 1-(1-phenylcyclohexyl)ethan-1-ol (1344924-39-5) + 1-(1-phenylcyclohexyl)ethan-1-ol (1344956-92-8) + (3,5-dimethylphenyl)dimethyl(1-(1-phenylcyclohexyl)ethoxy)silane + (3,5-dimethylphenyl)dimethyl(1-(1-phenylcyclohexyl)ethoxy)silane

Guidance literature:

(3,5-dimethylphenyl)dimethylsilane; With copper(l) chloride; sodium t-butanolate; (R,R)-1,2-bis(2,5-diphenylphospholanyl)ethane; In toluene; at 20 ℃; for 0.166667h; Glovebox; Inert atmosphere;

rac-1-(1-phenylcyclohexyl)ethan-1-ol; In toluene; at 20 ℃; for 144h; enantioselective reaction; Glovebox; Inert atmosphere; Resolution of racemate;

DOI:10.1021/acs.orglett.0c03943

Reference yield:

1-(1-phenylcyclohexyl)ethanone (3183-57-1) → 1-(1-phenylcyclohexyl)ethan-1-ol (1344924-39-5) + 1-(1-phenylcyclohexyl)ethan-1-ol (1344956-92-8)

Guidance literature:

With methanol; sodium tetrahydroborate; 1,1,1-trichloroethane; (1S,2S)-N,N'-bis[3-oxo-2-(2,4,6-trimethylbenzoyl)butylidene]-1,2-bis(2,4,6-trimethylphenyl)ethylenediaminatocobalt(II); In tetrahydrofuran; at -20 - 0 ℃; for 96.3333h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1246/cl.2012.780

upstream raw materials:

1,5-dibromo-pentane

1-phenyl-acetone

1-(1-phenylcyclohexyl)ethanone

rac-1-(1-phenylcyclohexyl)ethan-1-ol

Refernces

• 1、 Tsubo, Tatsuyuki,Chen, Hsiu-Hui,Yokomori, Minako,Fukui, Kosuke,Kikuchi, Satoshi,Yamada, Tohru. "Enantioselective borohydride reduction of aliphatic ketones catalyzed by ketoiminatocobalt(iii) complex with 1-chlorovinyl axial ligand". . p. 780 - 782. Retrieved 2012/09/22.