5-hydroxymethyl-pyrrolidine-2-one

Base Information

• Chemical Name: 5-hydroxymethyl-pyrrolidine-2-one
• CAS No.: 62400-75-3
• Molecular Formula: C5H9NO2
• Molecular Weight: 115.132
• Hs Code.: 2933790090
• Mol file: 62400-75-3.mol

Synonyms:5-(Hydroxymethyl)-2-pyrrolidinone;5-Oxoprolenol;DL-5-(Hydroxymethyl)-2-pyrrolidinone;

Chemical Property of 5-hydroxymethyl-pyrrolidine-2-one

Chemical Property:

• Melting Point: 87 °C
• Boiling Point: 346 °C at 760 mmHg
• PKA: 14.35±0.10(Predicted)
• Flash Point: 163 °C
• PSA: 49.33000
• Density: 1.153 g/cm³
• LogP: -0.41390
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

5-(hydroxymethyl)-2-Pyrrolidinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-(hydroxymethyl)-2-Pyrrolidinone is a building block and an analog of Pramanicin which induces apoptosis in human colon cancer cells. 5-(hydroxymethyl)-2-Pyrrolidinone is also available with specified stereochemistry (P997525, H948310).

Technology Process of 5-hydroxymethyl-pyrrolidine-2-one

There total 15 articles about 5-hydroxymethyl-pyrrolidine-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5-hydroxymethyl-1-trimethylsilanyl-pyrrolidin-2-one → pyroglutamol (62400-75-3)

Guidance literature:

With silica gel; In diethyl ether;

DOI:10.1055/s-2006-942354

Reference yield: 85.0%

N-[(mesitylcarbonyl)oxy]pent-4-enamide (1159991-66-8) → pyroglutamol (62400-75-3)

Guidance literature:

N-[(mesitylcarbonyl)oxy]pent-4-enamide; With potassium osmate; In water; acetonitrile; tert-butyl alcohol;

With sodium sulfite; In water; acetonitrile; tert-butyl alcohol;

DOI:10.1021/ol900631y

Reference yield: 83.0%

methyl 5-oxopyrrolidine-2-carboxylate (4931-66-2,54571-66-3,64700-65-8) → pyroglutamol (62400-75-3)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 2h; Inert atmosphere;

upstream raw materials:

5-(iodomethyl)-2-pyrrolidinone

1,4-dioxane

(S)-butyl 5-oxopyrrolidine-2-carboxylate

pent-4-enoic acid

Downstream raw materials:

5-(acetoxymethyl)-2-pyrrolidinone

(3R,7aS)-3-Phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one

(racemic)-5-(2'-propenyl)-2-pyrrolidinone

(4S,6aR,10R,12aS)-4,10-Diphenyl-octahydro-5,11-dioxa-3a,9a-diaza-dicyclopenta[a,f]cyclodecene-3,9-dione

Refernces

• 1、 -. "FUSED MORPHOLINOPYRIMIDINES AND METHODS OF USE THEREOF". Paragraph 1239. . Retrieved 2015/08/03.
• 2、 -. "PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS". . . Retrieved 2010/03/02.