ethyl cyano[2-fluoro-4-(trifluoromethyl)phenyl]acetate

Base Information

• Chemical Name: ethyl cyano[2-fluoro-4-(trifluoromethyl)phenyl]acetate
• CAS No.: 1257088-55-3
• Molecular Formula: C₁₂H₉F₄NO₂
• Molecular Weight: 275.203
• Mol file: 1257088-55-3.mol

Synonyms:ethyl cyano[2-fluoro-4-(trifluoromethyl)phenyl]acetate

Chemical Property of ethyl cyano[2-fluoro-4-(trifluoromethyl)phenyl]acetate

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl cyano[2-fluoro-4-(trifluoromethyl)phenyl]acetate

There total 2 articles about ethyl cyano[2-fluoro-4-(trifluoromethyl)phenyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-difluoro-4-(trifluoromethyl)benzene (32137-19-2) + ethyl 2-cyanoacetate (105-56-6) → ethyl cyano[2-fluoro-4-(trifluoromethyl)phenyl]acetate (1257088-55-3)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; In dimethyl sulfoxide; at 90 ℃; Inert atmosphere;

Reference yield:

1,2-difluoro-4-(trifluoromethyl)benzene (32137-19-2) + ethyl 2-cyanoacetate (105-56-6) → ethyl cyano[2-fluoro-4-(trifluoromethyl)phenyl]acetate (1257088-55-3) + ethyl cyano[2-fluoro-5-(trifluoromethyl)phenyl]acetate

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; In dimethyl sulfoxide; at 90 ℃; for 20h; Inert atmosphere;

DOI:10.1055/s-0030-1257871

Reference yield:

ethyl cyano[2-fluoro-4-(trifluoromethyl)phenyl]acetate (1257088-55-3) → [2-fluoro-4-(trifluoromethyl)phenyl]acetonitrile (239087-11-7)

Guidance literature:

With water; sodium chloride; In dimethyl sulfoxide; at 110 ℃;

DOI:10.1055/s-0030-1257871

upstream raw materials:

1,2-difluoro-4-(trifluoromethyl)benzene

ethyl 2-cyanoacetate

Downstream raw materials:

[2-fluoro-4-(trifluoromethyl)phenyl]acetonitrile

1-[2-fluoro-4-(trifluoromethyl)phenyl]cyclopropanecarbonitrile

Refernces

• 1、 Stazi, Federica,Maton, William,Castoldi, Damiano,Westerduin, Pieter,Curcuruto, Ornella,Bacchi, Sergio. "Efficient methods for the synthesis of arylacetonitriles". experimental part. p. 3332 - 3338. Retrieved 2010/11/20.