2,3-Dihydro-5-benzofuranethanol

Base Information

• Chemical Name: 2,3-Dihydro-5-benzofuranethanol
• CAS No.: 87776-76-9
• Molecular Formula: C10H12O2
• Molecular Weight: 164.204
• Hs Code.: 2932990090
• Mol file: 87776-76-9.mol

Synonyms:2-(2,3-Dihydrobenzofuran-5-yl)ethanol;5-(2-Hydroxyethyl)-2,3-dihydrobenzofuran;

Chemical Property of 2,3-Dihydro-5-benzofuranethanol

Chemical Property:

• Vapor Pressure: 0.000717mmHg at 25°C
• Refractive Index: 1.579
• Boiling Point: 294.8 ºC
• Flash Point: 135 ºC
• PSA: 29.46000
• Density: 1.173 g/cm³
• LogP: 1.15630
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2,3-Dihydro-5-benzofuranethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,3-Dihydro-5-benzofuranethanol is an intermediate in the synthesis of Darifenacin (D193400, HBr); a medication used to treat urinary incontinence. It works by blocking the M3 muscarinic acetylcholine receptor.

Technology Process of 2,3-Dihydro-5-benzofuranethanol

There total 13 articles about 2,3-Dihydro-5-benzofuranethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,3-dihydrobenzofuran-5-acetic acid (69999-16-2) → 5-(2-hydroxyethyl)-2,3-dihydrobenzofuran (87776-76-9)

Guidance literature:

2,3-dihydrobenzofuran-5-acetic acid; With borane-THF; In tetrahydrofuran; at 0 - 20 ℃; for 20h;

With water; In tetrahydrofuran;

Reference yield: 92.0%

tert-butyl(2-(2,3-dihydrobenzofuran-5-yl)ethoxy)dimethylsilane → 5-(2-hydroxyethyl)-2,3-dihydrobenzofuran (87776-76-9)

Guidance literature:

With 2,6-disulphated cellulose; In methanol; at 25 ℃; for 0.333333h; Green chemistry;

DOI:10.1039/c8ob01438h

Reference yield: 79.0%

ethyl 2,3-dihydrobenzofuran-5-ylacetate (69999-18-4) → 5-(2-hydroxyethyl)-2,3-dihydrobenzofuran (87776-76-9)

Guidance literature:

ethyl 2,3-dihydrobenzofuran-5-ylacetate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

With water; In tetrahydrofuran;

upstream raw materials:

2,3-dihydrobenzofuran-5-acetic acid

methyl 2-(2,3-dihydrobenzofuran-5-yl)acetate

2-(2,3-dihydrobenzofuran-5-yl)acetaldehyde bisulfitic complex

ethyl 2,3-dihydrobenzofuran-5-ylacetate

Downstream raw materials:

C₂₃H₂₅NO₃

(S)-darifenacin hydrobromide

2-(2,3-dihydrobenzofuran-5-yl)ethylchloride

2-(2,3-dihidrobenzofuran-5-yl)ethyl tosylate

Refernces

• 1、 -. "Novel preparation method of darifenacin intermediate 2,3-dihydro-5-benzofuran acetic acid". Paragraph 0050; 0051; 0052. . Retrieved 2018/04/03.
• 2、 -. "SUBSTITUTED PYRROLIDINES". Page/Page column 31. . Retrieved 2009/01/24.