Pyridine-2-sulfonyl chloride hydrochloride

Base Information

• Chemical Name: Pyridine-2-sulfonyl chloride hydrochloride
• CAS No.: 111480-84-3
• Molecular Formula: C5H4ClNO2S^.HCl
• Molecular Weight: 214.072
• European Community (EC) Number: 689-718-9
• DSSTox Substance ID: DTXSID60549546
• Mol file: 111480-84-3.mol

Synonyms:111480-84-3;Pyridine-2-sulfonyl chloride hydrochloride;2-pyridinesulfonyl chloride hydrochloride;2-Pyridinesulfonyl Chloride, Hydrochloride;pyridine-2-sulfonyl chloride;hydrochloride;2-Chlorosulfonyl-pyridinium chloride;Pyridine-2-sulfonyl Chloride Monohydrochloride;SCHEMBL17129;DTXSID60549546;Pyridine-2-sulfonyl chloride HCl;XAJWHCVLZBSLNC-UHFFFAOYSA-N;MFCD03410295;AKOS015912285;AB14073;Pyridine-2-sulfonylchloridehydrochloride;2-pyridylsulphonyl chloride hydrochloride;pyridine-2sulfonyl chloride hydrochloride;CS-0451177;2-Pyridinesulfonylchloride,hydrochloride(1:1);pyridine-2-sulfonyl chloride hydrochloride salt;A802370;W-204754;Pyridine-2-sulfonyl chloride--hydrogen chloride (1/1)

Chemical Property of Pyridine-2-sulfonyl chloride hydrochloride

Chemical Property:

• Appearance/Colour: Off-white solid
• Vapor Pressure: 0.000344mmHg at 25°C
• Melting Point: 77-81°C
• Boiling Point: 314.4 °C at 760 mmHg
• Flash Point: 143.9 °C
• PSA: 55.41000
• LogP: 2.89190
• Storage Temp.: Keep Cold
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 212.9418050
• Heavy Atom Count: 11
• Complexity: 196

Purity/Quality:

99% ^*data from raw suppliers

2-PyridinesulfonylChlorideHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R34:
• Hazard Codes: Xi
• Statements: 34-36
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)S(=O)(=O)Cl.Cl
• Uses: 2-Pyridinesulfonyl Chloride Hydrochloride is a useful reactant for the preparation of benzamides as 11β-hydroxysteroid dehydrogenase type 1 modulators for the treatment of metabolic syndromes. 2-Chlorosulfonyl-pyridinium chloride is used for preparation of piperidine derivatives as tachykinin receptor antagonists.

Technology Process of Pyridine-2-sulfonyl chloride hydrochloride

There total 1 articles about Pyridine-2-sulfonyl chloride hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.8%

2-Sulfanylpyridine (2637-34-5,73018-10-7) → Pyridyl-2-sulfonyl chloride hydrochloride (111480-84-3)

Guidance literature:

With hydrogenchloride; chlorine; at 0 ℃; for 1.5h;

DOI:10.1055/s-1987-27967

Reference yield: 78.0%

methanol (67-56-1) + Pyridyl-2-sulfonyl chloride hydrochloride (111480-84-3) → Pyridine-2-sulfonic acid methyl ester (111480-82-1)

Guidance literature:

With pyridine; at 0 ℃;

DOI:10.1055/s-1987-27967

Reference yield:

Pyridyl-2-sulfonyl chloride hydrochloride (111480-84-3) → pyridine-2-sulfonyl chloride (66715-65-9)

Guidance literature:

In dichloromethane;

DOI:10.1080/17415993.2020.1775834

upstream raw materials:

2-Sulfanylpyridine

Downstream raw materials:

Pyridine-2-sulfonic acid methyl ester

5-Methyl-N-[1-(5-methylfuran-2-yl)-propyl]-2-(pyridine-2-sulfonylamino)-benzamide

7-[(pyridine-2-sulfonyl)-(4-thiazol-2-yl-benzyl)-amino]-heptanoic acid methyl ester

7-[(4-pyrazol-1-yl-benzyl)-(pyridine-2-sulfonyl)-amino]-heptanoic acid methyl ester

Refernces

• 1、 Hanessian, Stephen,Kagotani, Masahiro. "A Novel Regiospecific Synthesis of 2-Substituted Pyridines". . p. 409 - 411. Retrieved 2007/10/02.