3-IODO-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBOXYLICACIDMETHYLESTER

Base Information

• Chemical Name: 3-IODO-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBOXYLICACIDMETHYLESTER
• CAS No.: 944937-30-8
• Molecular Formula: C9H7IN2O2
• Molecular Weight: 302.07
• Hs Code.: 2933990090
• Mol file: 944937-30-8.mol

Synonyms:3-Iodo-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester;Methyl 3-iodo-1H-pyrrolo[3,2-e]pyridine-5-carboxylate;3-Iodo-7-azaindole-5-carboxylic acid methyl ester;

Chemical Property of 3-IODO-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBOXYLICACIDMETHYLESTER

Chemical Property:

• Refractive Index: 1.72
• PKA: 11.47±0.40(Predicted)
• PSA: 54.98000
• Density: 1.948 g/cm³
• LogP: 1.95410
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%Min ^*data from raw suppliers

3-Iodo-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Iodo-1h-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester

Technology Process of 3-IODO-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBOXYLICACIDMETHYLESTER

There total 2 articles about 3-IODO-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBOXYLICACIDMETHYLESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.19%

1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester (849067-96-5) → methyl 3-iodo-1H-pyrrolo[2,3-b]pyridine-5-carboxylate (944937-30-8)

Guidance literature:

With N-iodo-succinimide; In acetone; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

5-bromo-1H-pyrrolo[2,3-b]pyridine (183208-35-7) → methyl 3-iodo-1H-pyrrolo[2,3-b]pyridine-5-carboxylate (944937-30-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 10 h / 100 °C

2: N-iodo-succinimide / acetone / 1 h / 20 °C / Inert atmosphere

With N-iodo-succinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; triethylamine; In acetone;

Reference yield: 82.0%

di-tert-butyl dicarbonate (24424-99-5) + methyl 3-iodo-1H-pyrrolo[2,3-b]pyridine-5-carboxylate (944937-30-8) → 1-tert-butyl 5-methyl 3-iodo-1H-pyrrolo[2,3-b]pyridine-1,5-dicarboxylate (1403746-51-9)

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; at 20 ℃; for 16h;

upstream raw materials:

1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester

5-bromo-1H-pyrrolo[2,3-b]pyridine

Downstream raw materials:

1-tert-butyl 5-methyl 3-iodo-1H-pyrrolo[2,3-b]pyridine-1,5-dicarboxylate

Refernces

• 1、 -. "SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS". Page/Page column 25. . Retrieved 2012/11/07.