POTASSIUM NICOTINATE

Base Information

• Chemical Name: POTASSIUM NICOTINATE
• CAS No.: 16518-17-5
• Molecular Formula: C6H5 N O2 . K
• Molecular Weight: 161.202
• Hs Code.: 2933399090
• Mol file: 16518-17-5.mol

Synonyms:3-Pyridinecarboxylicacid, potassium salt (9CI); Nicotinic acid, potassium salt (8CI); Potassium3-pyridinecarboxylate; Potassium nicotinate

Chemical Property of POTASSIUM NICOTINATE

Chemical Property:

• Vapor Pressure: 0.000836mmHg at 25°C
• Melting Point: 236.6oC
• Boiling Point: 292.5°Cat760mmHg
• Flash Point: 130.7°C
• PSA: 53.02000
• Density: 1.293g/cm³
• LogP: -0.55490

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s): Low toxicity by ingestion.
• Hazard Codes: Low toxicity by ingestion.

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of POTASSIUM NICOTINATE

There total 4 articles about POTASSIUM NICOTINATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

nicotinic acid (59-67-6) → potassium nicotinate (16518-17-5)

Guidance literature:

With potassium tert-butylate; In ethanol; at 20 ℃; Inert atmosphere;

DOI:10.1002/chem.200900892

Reference yield: 90.0%

methyl 3-pyridinecarboxylate (93-60-7) + potassium trimethylsilonate (10519-96-7) → potassium nicotinate (16518-17-5)

Guidance literature:

In tetrahydrofuran;

Reference yield: 63.0%

3-Pyridinecarbaldehyde phenylhydrazone (57023-37-7) → potassium nicotinate (16518-17-5)

Guidance literature:

With potassium trimethylsilonate; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1002/ejoc.201601238

upstream raw materials:

methyl 3-pyridinecarboxylate

potassium trimethylsilonate

nicotinic acid

3-Pyridinecarbaldehyde phenylhydrazone

Downstream raw materials:

hexadecyl nicotinate

4-(3-pyridyl)toluene

3-<3-(trifluoromethyl)phenyl>pyridine

3-(4-methoxyphenyl)pyridine

Refernces

• 1、 Burglova, Kristyna,Okorochenkov, Sergei,Budesinsky, Milos,Hlavac, Jan. "Efficient Method for Aromatic-Aldehyde Oxidation by Cleavage of Their Hydrazones Catalysed by Trimethylsilanolate". . p. 389 - 396. Retrieved 2017/01/24.
• 2、 Goossen, Luksa J.,Rodriguez, Nuria,Lange, Paul P.,Linder, Christophe. "Decarboxylative cross-coupling of aryl tosylates with aromatic carboxylate salts". supporting information; experimental part. p. 1111 - 1114. Retrieved 2010/04/29.