C₂₅H₁₈FNO

Base Information

• Chemical Name: C₂₅H₁₈FNO
• CAS No.: 1361017-61-9
• Molecular Formula: C₂₅H₁₈FNO
• Molecular Weight: 367.422
• Mol file: 1361017-61-9.mol

Synonyms:C₂₅H₁₈FNO

Chemical Property of C₂₅H₁₈FNO

Chemical Property:

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Technology Process of C₂₅H₁₈FNO

There total 1 articles about C₂₅H₁₈FNO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

5-fluoro-1-benzylindolin-2-one + 3-(3-methylphenyl)prop-2-ynal (62358-91-2) → C25H18FNO (1361017-61-9) + C35H28FNO3

Guidance literature:

With potassium tert-butylate; 1,3-bis(mesityl)imidazolium chloride; In tetrahydrofuran; at 20 - 65 ℃; for 2h; optical yield given as %de; diastereoselective reaction; Molecular sieve; Inert atmosphere;

DOI:10.1021/ol300148f

upstream raw materials:

3-(3-methylphenyl)prop-2-ynal

Refernces