5-phenyl-2,3,4,7-tetrahydro-1H-azepine

Base Information

• Chemical Name: 5-phenyl-2,3,4,7-tetrahydro-1H-azepine
• CAS No.: 324784-93-2
• Molecular Formula: C₁₂H₁₅N
• Molecular Weight: 173.258
• Mol file: 324784-93-2.mol

Synonyms:5-phenyl-2,3,4,7-tetrahydro-1H-azepine

Chemical Property of 5-phenyl-2,3,4,7-tetrahydro-1H-azepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-phenyl-2,3,4,7-tetrahydro-1H-azepine

There total 9 articles about 5-phenyl-2,3,4,7-tetrahydro-1H-azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

C17H25NO3 (1422424-42-7) → 5-phenyl-2,3,4,7-tetrahydro-1H-azepine (324784-93-2) + 4-phenyl-2,3,6,7-tetrahydro-1H-azepine (324784-95-4)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃; for 1h;

Reference yield:

4-phenyl-azepan-4-ol (1202-87-5) → 5-phenyl-2,3,4,7-tetrahydro-1H-azepine (324784-93-2) + 4-phenyl-2,3,6,7-tetrahydro-1H-azepine (324784-95-4)

Guidance literature:

4-phenyl-azepan-4-ol; With hydrogenchloride; acetic acid; In water; at 120 ℃; for 4h;

With sodium hydroxide; water;

Reference yield:

bromobenzene (108-86-1,52753-63-6) → 5-phenyl-2,3,4,7-tetrahydro-1H-azepine (324784-93-2) + 4-phenyl-2,3,6,7-tetrahydro-1H-azepine (324784-95-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: magnesium; iodine / tetrahydrofuran / 1 h / Inert atmosphere

1.2: 12 h / 0 - 20 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / toluene / 1 h / Reflux

With iodine; toluene-4-sulfonic acid; magnesium; In tetrahydrofuran; toluene;

DOI:10.1039/c8ob01273c

upstream raw materials:

4-phenyl-azepan-4-ol

tert-butyl 4-oxoazepane-1-carboxylate

phenylmagnesium chloride

C₁₇H₂₅NO₃

Downstream raw materials:

C₁₉H₂₁NO₃S

C₁₉H₂₁NO₃S

C₂₃H₂₃N₃O₂

Refernces

• 1、 -. "NEW ANTIBACTERIAL COMPOUNDS". Page/Page column 38. . Retrieved 2014/03/21.
• 2、 -. "ANTIBACTERIAL HOMOPIPERIDINYL SUBSTITUTED 3,4 DIHYDRO 1H [1,8]NAPHTHYRIDINONES". . . Retrieved 2013/03/26.