5-CHLORO-2-ISOCYANOPYRIDINE

Base Information

• Chemical Name: 5-CHLORO-2-ISOCYANOPYRIDINE
• CAS No.: 1027746-23-1
• Molecular Formula: C₆H₃ClN₂
• Molecular Weight: 138.556
• Mol file: 1027746-23-1.mol

Synonyms:5-chloro-2-pyridyl isonitrile

Chemical Property of 5-CHLORO-2-ISOCYANOPYRIDINE

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5-CHLORO-2-ISOCYANOPYRIDINE

There total 1 articles about 5-CHLORO-2-ISOCYANOPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

N-(5-chloropyridin-2-yl)formamide (457957-85-6) → 5-chloro-2-pyridyl isonitrile (1027746-23-1)

Guidance literature:

With triethylamine; trichlorophosphate; In dichloromethane; at -78 - 0 ℃;

DOI:10.1021/acs.orglett.6b00091

Reference yield: 50.0%

5-chloro-2-pyridyl isonitrile (1027746-23-1) + 2-isocyano-1-morpholino-3-(p-tolyl)propan-1-one → 6-chloro-3-(4-methylbenzyl)-2-morpholino-1,8-naphthyridin-4(1H)-one

Guidance literature:

With lithium carbonate; silver carbonate; In acetonitrile; at 100 ℃; for 12h; chemoselective reaction; Sealed tube;

DOI:10.1002/anie.201611024

Reference yield: 46.0%

7,7-dimethyl-3,3-pentamethylene-1-phenyl-8-oxa-1,5,6-triazaspiro[3.4]oct-5-en-2-one (1087654-07-6) + 5-chloro-2-pyridyl isonitrile (1027746-23-1) → (6-chloro-3-(5-chloropyridin-2-ylamino)imidazo[1,2-a]-pyridin-2-yl)(cyclohexyl)methanone (1332480-23-5)

Guidance literature:

7,7-dimethyl-3,3-pentamethylene-1-phenyl-8-oxa-1,5,6-triazaspiro[3.4]oct-5-en-2-one; 5-chloro-2-pyridyl isonitrile; In 1,4-dioxane; Inert atmosphere; Reflux;

With sulfuric acid; In 1,4-dioxane; water; Inert atmosphere; Reflux;

DOI:10.1021/jo201273p

upstream raw materials:

N-(5-chloropyridin-2-yl)formamide

Downstream raw materials:

(6-chloro-3-(5-chloropyridin-2-ylamino)imidazo[1,2-a]-pyridin-2-yl)(cyclohexyl)methanone

Refernces